Tag: Cold

  • Unsheltered people are losing Medicaid in redetermination mix-ups

    Unsheltered people are losing Medicaid in redetermination mix-ups

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    Evans said she lost Medicaid coverage in September because she hadn’t received paperwork after moving from Great Falls, Montana. She has had to forgo the blood pressure medication she can no longer pay for since losing coverage. She has also had to put off needed dental work.

    “The teeth broke off. My gums hurt. There’s some times where I’m not feeling good, I don’t want to eat,” she said.

    Evans is one of about 130,000 Montanans who have lost Medicaid coverage as the state reevaluates everyone’s eligibility following a pause in disenrollments during the covid-19 pandemic. About two-thirds of those who were kicked off state Medicaid rolls lost coverage for technical reasons, such as incorrectly filling out paperwork. That’s one of the highest procedural disenrollment rates in the nation, according to a KFF analysis.

    Even unsheltered people like Evans are losing their coverage, despite state officials saying they would automatically renew people who should still qualify by using Social Security and disability data.

    As other guests filtered out of the shelter that February morning, Evans sat down in a spare office with an application counselor from Greater Valley Health Clinic, which serves much of the homeless population here, and recounted her struggle to reenroll.

    She said that she had asked for help at the state public assistance office, but that the staff didn’t have time to answer her questions about which forms she needed to fill out or to walk her through the paperwork. She tried the state’s help line, but couldn’t get through.

    “You just get to the point where you’re like, ‘I’m frustrated right now. I just have other things that are more important, and let’s not deal with it,’” she said.

    Evans has a job and spends her free time finding a place to sleep since she doesn’t have housing. Waiting on the phone most of the day isn’t feasible.

    There’s no public data on how many unhoused people in Montana or nationwide have lost Medicaid, but homeless service providers and experts say it’s a big problem.

    Those assisting unsheltered people who have lost coverage say they spend much of their time helping people contact the Montana Medicaid office. Sorting through paperwork mistakes is also a headache, said Crystal Baker, a case manager at HRDC, a homeless shelter in Bozeman.

    “We’re getting mail that’s like, ‘Oh, this needs to be turned in by this date,’ and that’s already two weeks past. So, now we have to start the process all over again,” she said. “Now, they have to wait two to three months without insurance.”

    Montana health officials told NPR and KFF Health News in a statement that they provided training to help homeless service agencies prepare their clients for redetermination.

    Federal health officials have warned Montana and some other conservative states against disenrolling high rates of people for technicalities, also known as procedural disenrollment. They also warned states about unreasonable barriers to accessing help, such as long hold times on help lines. The Centers for Medicare & Medicaid Services said if states don’t reduce the rate of procedural disenrollments, the agency could force them to halt their redetermination process altogether. So far, CMS hasn’t taken that step.

    Charlie Brereton, the director of the Montana health department, resisted calls from Democratic state lawmakers to pause the redetermination process. Redetermination ended in January, four months ahead of the federal deadline.

    “I’m confident in our redetermination process,” Brereton told lawmakers in December. “I do believe that many of the Medicaid members who’ve been disenrolled were disenrolled correctly.

    Health industry observers say that both liberal-leaning and conservative-leaning states are kicking homeless people off their rolls and that the redetermination process has been chaotic everywhere. Because of the barriers that unsheltered people face, it’s easy for them to fall through the cracks.

    Margot Kushel, a physician and a homeless researcher at the University of California-San Francisco, said it may not seem like a big deal to fill out paperwork. But, she said, “put yourself in the position of an elder experiencing homelessness,” especially those without access to a computer, phone, or car.

    If they still qualify, people can usually get their Medicaid coverage renewed — eventually — and it may reimburse patients retroactively for care received while they were unenrolled.

    Kushel said being without Medicaid for any period can be particularly dangerous for people who are homeless. This population tends to have high rates of chronic health conditions.

    “Being out of your asthma medicine for three days can be life-threatening. If you have high blood pressure and you suddenly stop your medicine, your blood pressure shoots up, and your risk of having a heart attack goes way up,” she said.

    When people don’t understand why they’re losing coverage or how to get it back, that erodes their trust in the medical system, Kushel said.

    Evans, the homeless woman, was able to get help with her application and is likely to regain coverage.

    Agencies that serve unhoused people said it could take years to get everyone who lost coverage back on Medicaid. They worry that those who go without coverage will resort to using the emergency room rather than managing their health conditions proactively.

    Baker, the case manager at the Bozeman shelter, set up several callbacks from the state Medicaid office for one client. The state needed to interview him to make sure he still qualified, but the state never called.

    “He waited all day long. By the fifth time, it was so stressful for him, he just gave up,” she said.

    That client ended up leaving the Bozeman area before Baker could convince him it was worth trying to regain Medicaid.

    Baker worries his poor health will catch up with him before he decides to try again.




    Kaiser Health NewsThis article was reprinted from khn.org, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – the independent source for health policy research, polling, and journalism.

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  • B Medical Systems’ Solar Direct Vaccine Refrigerator and Ice-Pack Freezer, the TCW40SDD, Receives the ACT Label

    B Medical Systems’ Solar Direct Vaccine Refrigerator and Ice-Pack Freezer, the TCW40SDD, Receives the ACT Label

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    B Medical Systems, a leading player in the medical cold chain industry, is proud to announce that its Solar Direct Drive Vaccine Refrigerator and Ice-Pack Freezer, TCW40SDD, has received the prestigious ACT label from My Green Lab. This recognition is a testament to B Medical Systems’ unwavering commitment to sustainability and its relentless pursuit of environmental excellence in medical cold chain solutions. TCW40SDD is the first ever Solar Direct Drive Vaccine Refrigerator and Ice-Pack Freezer to receive an ACT label.

    B Medical Systems, a leading player in the medical cold chain industry, is proud to announce that its Solar Direct Drive Vaccine Refrigerator and Ice-Pack Freezer, TCW40SDD, has received the prestigious ACT label from My Green Lab.

    Image Credit: B Medical Systems

    The ACT standing for Accountability, Consistency, and Transparency label, was designed to address the need of both scientists and procurement specialists for clear, third-party verified information about the environmental impact of laboratory products. Its criteria, also known as the Environmental Impact Factor (EIF) criteria, were developed with input from industry experts and external stakeholders. The ACT label process entails third-party verification of the sustainable impacts of a product its operations, and its end of life.

    The TCW40SDD is a solar-powered vaccine refrigerator and ice-pack freezer and uses R600a as its refrigerant. A WHO PQS prequalified solution, this product offers 46.6 L and 4.8 L of gross volume in its refrigerator and freezer compartments, respectively, and can operate in ambient conditions up to 43 °C. The TCW40SDD has a hold over time of over 93 hours at an ambient temperature of 43 °C, making it a trusted solution in many countries around the world where access to reliable electricity can be a challenge.

    Luc Provost, CEO of B Medical Systems, expressed his pride in this achievement, stating, “Receiving the ACT label for our TCW40SDD model is a significant milestone that reflects our deep-rooted commitment to sustainability. It is a recognition of our efforts to innovate while keeping environmental stewardship at the forefront of our operations. This not only highlights the exceptional quality and reliability of our products but also aligns with our vision to lead the medical cold chain manufacturing industry towards a more sustainable future.”

    Source: https://www.bmedicalsystems.com/en

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  • Antibiotics ineffective for cough treatment in lower respiratory tract infections

    Antibiotics ineffective for cough treatment in lower respiratory tract infections

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    Use of antibiotics provided no measurable impact on the severity or duration of coughs even if a bacterial infection was present, finds a large, prospective study of people who sought treatment in U.S. primary or urgent care settings for lower-respiratory tract infections.

    The study by researchers at Georgetown University Medical Center and colleagues appeared April 15, 2024, in the Journal of General Internal Medicine.

    Upper respiratory tract infections usually include the common cold, sore throat, sinus infections and ear infections and have well established ways to determine if antibiotics should be given. Lower respiratory tract infections tend to have the potential to be more dangerous, since about 3% to 5% of these patients have pneumonia. But not everyone has easy access at an initial visit to an X-ray, which may be the reason clinicians still give antibiotics without any other evidence of a bacterial infection. Plus, patients have come to expect antibiotics for a cough, even if it doesn’t help. Basic symptom-relieving medications plus time brings a resolution to most people’s infections.”


    Dan Merenstein, MD, professor of family medicine at Georgetown University School of Medicine

    The antibiotics prescribed in this study for lower tract infections were all appropriate, commonly used antibiotics to treat bacterial infections. But the researchers’ analysis showed that of the 29% of people given an antibiotic during their initial medical visit, there was no effect on the duration or overall severity of cough compared to those who didn’t receive an antibiotic.

    “Physicians know, but probably overestimate, the percentage of lower tract infections that are bacterial; they also likely overestimate their ability to distinguish viral from bacterial infections,” says Mark H. Ebell, MD, MS, a study author and professor in the College of Public Health at the University of Georgia. “In our analysis, 29% of people were prescribed an antibiotic while only 7% were given an antiviral. But most patients do not need antivirals as there exist only two respiratory viruses where we have medications to treat them: influenza and SARS-COV-2. There are none for all of the other viruses.”

    To determine if there was an actual bacterial or viral infection present, beyond the self-reported symptoms of a cough, the investigators confirmed the presence of pathogens with advanced lab tests to look for microbiologic results classified as only bacteria, only viruses, both virus and bacteria, or no organism detected. Very importantly, for those with a confirmed bacterial infection, the length of time until illness resolution was the same for those receiving an antibiotic versus those not receiving one – about 17 days.

    Overuse of antibiotics can result in dizziness, nausea, diarrhea, and rash along with about a 4% chance of serious adverse effects including anaphylaxis, which is a severe, life-threatening allergic reaction; Stevens-Johnson syndrome, a rare, serious disorder of the skin and mucous membranes; and Clostridioides difficile-associated diarrhea. Another significant concern of the overuse of antibiotics is resistance. The World Health Organization released a statement on April 4, 2024, stating: “Uncontrolled antimicrobial resistance [due to the overuse of antibiotics] is expected to lower life expectancy and lead to unprecedented health expenditure and economic losses.”

    “We know that cough can be an indicator of a serious problem. It is the most common illness-related reason for an ambulatory care visit, accounting for nearly 3 million outpatient visits and more than 4 million emergency department visits annually,” says Merenstein. “Serious cough symptoms and how to treat them properly needs to be studied more, perhaps in a randomized clinical trial as this study was observational and there haven’t been any randomized trials looking at this issue since about 2012.”

    In addition to Merenstein and Ebell, the other co-author is Bruce Barrett MD, PhD at the University of Wisconsin, Madison,

    This work was supported by an AHRQ grant R01HS025584.

    Source:

    Journal reference:

    Merenstein, D.J., et al. (2024) Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection. Journal of General Internal Medicine. doi.org/10.1007/s11606-024-08758-y.

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  • Meta-analysis uncovers stress-responsive genes in Arabidopsis

    Meta-analysis uncovers stress-responsive genes in Arabidopsis

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    Plants can be temperamental. Even weeds along the side of highways or pushing their way up in the cracks of concrete sidewalks can get stressed out by dehydration, cold, excess salt and more. Researchers at Hiroshima University have identified 14 genes that thale cress -; a plant commonly used in genetic investigations since its genome is well documented -; express more when responding to five specific stressors, as well as eight genes that the plant suppresses.

    They published their results on March 22 in Frontiers in Plant Science

    “Abiotic stresses -; as opposed to biotic stresses like pests or disease -; such as drought, salinity and cold negatively affect plant growth and crop productivity. Understanding the molecular mechanisms underlying plant responses to these stressors is essential for stress tolerance in crops,” said corresponding author Hidemasa Bono, professor in the Laboratory of Genome Informatics at Hiroshima University’s Graduate School of Integrated Sciences for Life. Bono is also affiliated with the Laboratory of Bio-DX in the university’s Genome Editing Innovation Center. 

    “The plant hormone abscisic acid (ABA) is significantly increased upon abiotic stressors, inducing physiological responses to adapt to stress and regulate gene expression. Although many studies have examined the components of established stress signaling pathways, few have explored other unknown elements.”

    To better understand the molecular pathways that allow ABA to increase, the research team analyzed public RNA sequencing data on thale cress, or Arabidopsis thaliana. RNA sequencing is a technique that enables scientists to identify and quantify specific sequences of genetic instructions programmed in an organism’s RNA. This data can reveal how different variables may increase or decrease the expression of certain genes.

    Bono and his team specifically focused on five ABA-related stress conditions: ABA, when the hormone is applied directly to the plant; salt, which changes how the plant can use water; dehydration, or how much water the plant has; osmotic, when plant cells swell or shrink inappropriately; and cold.

    The data-driven studies have the advantage of analyzing large and independent datasets, which can lead to the identification of novel targets, distinct from the extensively studied established factors and accelerate the development of stress-tolerant crops.”

    Hidemasa Bono, Professor, Laboratory of Genome Informatics at Hiroshima University’s Graduate School of Integrated Sciences for Life

    The researchers performed a meta-analysis of 216 paired datasets, combining those research results and reanalyzing them to identify where data might overlap or reveal previously unknown connections.

    The meta-analysis revealed that 14 genes were commonly up-regulated and eight genes were commonly down-regulated across all five ABA-related stress responses investigated. Bono noted that some genes regulated by salt, dehydration and osmotic treatments were not regulated by ABA or cold stress, suggesting that they may be involved in the plant response through a different signaling pathway.

    “Our meta-analysis revealed a list of candidate genes with unknown molecular mechanisms in ABA-dependent and ABA-independent stress responses,” Bono said.

    “These genes could be valuable resources for selecting genome editing targets and potentially contribute to the discovery of novel stress tolerance mechanisms and pathways in plants. We will continue to develop methods and utilize data from public databases and conduct comparative analysis from various angles to unravel the unknown mechanisms of stress response in plants.”

    Co-authors of the study are Mitsuo Shintani with the Graduate School of Integrated Sciences for Life at Hiroshima University and Keita Tamura with the university’s Genome Editing Innovation Center.

    The Center of Innovation for Bio-Digital Transformation (BioDX) and the Japan Science and Technology Agency supported this research.

    Source:

    Journal reference:

    Shintani, M., et al. (2024). Meta-analysis of public RNA sequencing data of abscisic acid-related abiotic stresses in Arabidopsis thaliana. Frontiers in Plant Science. doi.org/10.3389/fpls.2024.1343787.

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  • Proteotyping unveils new extremophiles in high-altitude lakes

    Proteotyping unveils new extremophiles in high-altitude lakes

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    Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets. In ACS’ Journal of Proteome Research, researchers detail a method for more accurate extremophile identification based on protein fragments instead of genetic material. The study identified two new hardy bacteria from high-altitude lakes in Chile -; an environment like early Mars.

    Even though humans tend to avoid settling in extremely hot, cold or high-altitude areas, some microorganisms have adapted to live in such harsh locations. These extremophile microbes are of interest to astrobiologists who are searching for life on other planets. Researchers currently use individual gene sequencing to identify Earth-bound microbes, based on their DNA. However, current methods can’t distinguish closely related species of extremophiles. So, Ralf Moeller and colleagues investigated whether they could identify an extremophile by using its protein signature rather than a gene sequence.

    The researchers started their demonstration with water samples from five high-altitude Andean lakes more than 2.3 miles above sea level in the Chilean Altiplano. (For reference, Denver is about one mile above sea level.) From the samples, the researchers cultivated 66 microbes and then determined which of two methods better identified the microorganisms:

    • Traditional gene sequencing compared the nucleotides of the 16s rRNA gene (a typical gene for sequence-based microbe analysis) from each sample to a database for identification.
    • The newer “proteotyping” technique analyzed protein fragments known as peptides to produce peptide signatures, which the team used to identify microorganisms from proteome databases.

    With these methods, the researchers identified 63 of the 66 microorganisms that were cultivated from the high-altitude lake samples. For the three microorganisms that gene sequencing failed to identify because their genetic information wasn’t in the available database, proteotyping identified two potentially new types of extremophile bacteria. These results suggest proteotyping could be a more complete solution for identifying extremophile microorganisms from small biological samples. The team says protein profiling could someday help us search for and identify extraterrestrial life and better explore the biodiversity on our own planet.

    Source:

    Journal reference:

    Runzheimer, K., et al. (2024). Exploring Andean High-Altitude Lake Extremophiles through Advanced Proteotyping. Journal of Proteome Research. doi.org/10.1021/acs.jproteome.3c00538.

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  • Researchers identify cold-sensing protein in mammals

    Researchers identify cold-sensing protein in mammals

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    University of Michigan researchers have identified the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology.

    The findings, published in Nature Neuroscience, could help unravel how we sense and suffer from cold temperatures in the winter, and why some patients experience cold differently under particular disease conditions.

    The field started uncovering these temperature sensors over 20 years ago, with the discovery of a heat-sensing protein called TRPV1.”


    Shawn Xu, neuroscientist, professor at the U-M Life Sciences Institute and senior author of the new research

    “Various studies have found the proteins that sense hot, warm, even cool temperatures-;but we’ve been unable to confirm what senses temperatures below about 60 degrees Fahrenheit.”

    In a 2019 study, researchers in Xu’s lab discovered the first cold-sensing receptor protein in Caenorhabditis elegans, a species of millimeter-long worms that the lab studies as a model system for understanding sensory responses.

    Because the gene that encodes the C. elegans protein is evolutionarily conserved across many species, including mice and humans, that finding provided a starting point for verifying the cold sensor in mammals: a protein called GluK2 (short for Glutamate ionotropic receptor kainate type subunit 2).

    For this latest study, a team of researchers from the Life Sciences Institute and the U-M College of Literature, Science, and the Arts tested their hypothesis in mice that were missing the GluK2 gene, and thus could not produce any GluK2 proteins. Through a series of experiments to test the animals’ behavioral reactions to temperature and other mechanical stimuli, the team found that the mice responded normally to hot, warm and cool temperatures, but showed no response to noxious cold.

    GluK2 is primarily found on neurons in the brain, where it receives chemical signals to facilitate communication between neurons. But it is also expressed in sensory neurons in the peripheral nervous system (outside the brain and spinal cord).

    We now know that this protein serves a totally different function in the peripheral nervous system, processing temperature cues instead of chemical signals to sense cold.”


    Bo Duan, U-M associate professor of molecular, cellular, and developmental biology and co-senior author of the study

    While GluK2 is best known for its role in the brain, Xu speculates that this temperature-sensing role may have been one of the protein’s original purposes. The GluK2 gene has relatives across the evolutionary tree, going all the way back to single-cell bacteria.

    “A bacterium has no brain, so why would it evolve a way to receive chemical signals from other neurons? But it would have great need to sense its environment, and perhaps both temperature and chemicals,” said Xu, who is also a professor of molecular and integrative physiology at the U-M Medical School. “So I think temperature sensing may be an ancient function, at least for some of these glutamate receptors, that was eventually co-opted as organisms evolved more complex nervous systems.”

    In addition to filling a gap in the temperature-sensing puzzle, Xu believes the new finding could have implications for human health and well-being. Cancer patients receiving chemotherapy, for example, often experience painful reactions to cold.

    “This discovery of GluK2 as a cold sensor in mammals opens new paths to better understand why humans experience painful reactions to cold, and even perhaps offers a potential therapeutic target for treating that pain in patients whose cold sensation is overstimulated,” Xu said. 

    The research was supported by the National Institutes of Health. All procedures performed in mice were approved by the Institutional Animal Care and Use Committee and performed in accordance with the institutional guidelines.

    Source:

    Journal reference:

    Cai, W., et al. (2024). The kainate receptor GluK2 mediates cold sensing in mice. Nature Neuroscience. doi.org/10.1038/s41593-024-01585-8.

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  • How a friend’s death turned Colorado teens into anti-overdose activists

    How a friend’s death turned Colorado teens into anti-overdose activists

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    Gavinn McKinney loved Nike shoes, fireworks, and sushi. He was studying Potawatomi, one of the languages of his Native American heritage. He loved holding his niece and smelling her baby smell. On his 15th birthday, the Durango, Colorado, teen spent a cold December afternoon chopping wood to help neighbors who couldn’t afford to heat their homes.

    McKinney almost made it to his 16th birthday. He died of fentanyl poisoning at a friend’s house in December 2021. His friends say it was the first time he tried hard drugs. The memorial service was so packed people had to stand outside the funeral home.

    Now, his peers are trying to cement their friend’s legacy in state law. They recently testified to state lawmakers in support of a bill they helped write to ensure students can carry naloxone with them at all times without fear of discipline or confiscation. School districts tend to have strict medication policies. Without special permission, Colorado students can’t even carry their own emergency medications, such as an inhaler, and they are not allowed to share them with others.

    “We realized we could actually make a change if we put our hearts to it,” said Niko Peterson, a senior at Animas High School in Durango and one of McKinney’s friends who helped write the bill. “Being proactive versus being reactive is going to be the best possible solution.”

    Individual school districts or counties in California, Maryland, and elsewhere have rules expressly allowing high school students to carry naloxone. But Jon Woodruff, managing attorney at the Legislative Analysis and Public Policy Association, said he wasn’t aware of any statewide law such as the one Colorado is considering. Woodruff’s Washington, D.C.-based organization researches and drafts legislation on substance use.

    Naloxone is an opioid antagonist that can halt an overdose. Available over the counter as a nasal spray, it is considered the fire extinguisher of the opioid epidemic, for use in an emergency, but just one tool in a prevention strategy. (People often refer to it as “Narcan,” one of the more recognizable brand names, similar to how tissues, regardless of brand, are often called “Kleenex.”)

    The Biden administration last year backed an ad campaign encouraging young people to carry the emergency medication.

    Most states’ naloxone access laws protect do-gooders, including youth, from liability if they accidentally harm someone while administering naloxone. But without school policies explicitly allowing it, the students’ ability to bring naloxone to class falls into a gray area.

    Ryan Christoff said that in September 2022 fellow staff at Centaurus High School in Lafayette, Colorado, where he worked and which one of his daughters attended at the time, confiscated naloxone from one of her classmates.

    “She didn’t have anything on her other than the Narcan, and they took it away from her,” said Christoff, who had provided the confiscated Narcan to that student and many others after his daughter nearly died from fentanyl poisoning. “We should want every student to carry it.”

    Boulder Valley School District spokesperson Randy Barber said the incident “was a one-off and we’ve done some work since to make sure nurses are aware.” The district now encourages everyone to consider carrying naloxone, he said.

    Community’s devastation turns to action

    In Durango, McKinney’s death hit the community hard. McKinney’s friends and family said he didn’t do hard drugs. The substance he was hooked on was Tapatío hot sauce — he even brought some in his pocket to a Rockies game.

    After McKinney died, people started getting tattoos of the phrase he was known for, which was emblazoned on his favorite sweatshirt: “Love is the cure.” Even a few of his teachers got them. But it was classmates, along with their friends at another high school in town, who turned his loss into a political movement.

    “We’re making things happen on behalf of him,” Peterson said.

    The mortality rate has spiked in recent years, with more than 1,500 other children and teens in the U.S. dying of fentanyl poisoning the same year as McKinney. Most youth who die of overdoses have no known history of taking opioids, and many of them likely thought they were taking prescription opioids like OxyContin or Percocet — not the fake prescription pills that increasingly carry a lethal dose of fentanyl.

    “Most likely the largest group of teens that are dying are really teens that are experimenting, as opposed to teens that have a long-standing opioid use disorder,” said Joseph Friedman, a substance use researcher at UCLA who would like to see schools provide accurate drug education about counterfeit pills, such as with Stanford’s Safety First curriculum.

    Allowing students to carry a low-risk, lifesaving drug with them is in many ways the minimum schools can do, he said.

    “I would argue that what the schools should be doing is identifying high-risk teens and giving them the Narcan to take home with them and teaching them why it matters,” Friedman said.

    Writing in The New England Journal of Medicine, Friedman identified Colorado as a hot spot for high school-aged adolescent overdose deaths, with a mortality rate more than double that of the nation from 2020 to 2022.

    “Increasingly, fentanyl is being sold in pill form, and it’s happening to the largest degree in the West,” said Friedman. “I think that the teen overdose crisis is a direct result of that.”

    If Colorado lawmakers approve the bill, “I think that’s a really important step,” said Ju Nyeong Park, an assistant professor of medicine at Brown University, who leads a research group focused on how to prevent overdoses. “I hope that the Colorado Legislature does and that other states follow as well.”

    Park said comprehensive programs to test drugs for dangerous contaminants, better access to evidence-based treatment for adolescents who develop a substance use disorder, and promotion of harm reduction tools are also important. “For example, there is a national hotline called Never Use Alone that anyone can call anonymously to be supervised remotely in case of an emergency,” she said.

    Taking matters into their own hands

    Many Colorado school districts are training staff how to administer naloxone and are stocking it on school grounds through a program that allows them to acquire it from the state at little to no cost. But it was clear to Peterson and other area high schoolers that having naloxone at school isn’t enough, especially in rural places.

    “The teachers who are trained to use Narcan will not be at the parties where the students will be using the drugs,” he said.

    And it isn’t enough to expect teens to keep it at home.

    “It’s not going to be helpful if it’s in somebody’s house 20 minutes outside of town. It’s going to be helpful if it’s in their backpack always,” said Zoe Ramsey, another of McKinney’s friends and a senior at Animas High School.

    “We were informed it was against the rules to carry naloxone, and especially to distribute it,” said Ilias “Leo” Stritikus, who graduated from Durango High School last year.

    But students in the area, and their school administrators, were uncertain: Could students get in trouble for carrying the opioid antagonist in their backpacks, or if they distributed it to friends? And could a school or district be held liable if something went wrong?

    He, along with Ramsey and Peterson, helped form the group Students Against Overdose. Together, they convinced Animas, which is a charter school, and the surrounding school district, to change policies. Now, with parental permission, and after going through training on how to administer it, students may carry naloxone on school grounds.

    Durango School District 9-R spokesperson Karla Sluis said at least 45 students have completed the training.

    School districts in other parts of the nation have also determined it’s important to clarify students’ ability to carry naloxone.

    “We want to be a part of saving lives,” said Smita Malhotra, chief medical director for Los Angeles Unified School District in California.

    Los Angeles County had one of the nation’s highest adolescent overdose death tallies of any U.S. county: From 2020 to 2022, 111 teens ages 14 to 18 died. One of them was a 15-year-old who died in a school bathroom of fentanyl poisoning. Malhotra’s district has since updated its policy on naloxone to permit students to carry and administer it.

    “All students can carry naloxone in our school campuses without facing any discipline,” Malhotra said. She said the district is also doubling down on peer support and hosting educational sessions for families and students.

    Montgomery County Public Schools in Maryland took a similar approach. School staff had to administer naloxone 18 times over the course of a school year, and five students died over the course of about one semester.

    When the district held community forums on the issue, Patricia Kapunan, the district’s medical officer, said, “Students were very vocal about wanting access to naloxone. A student is very unlikely to carry something in their backpack which they think they might get in trouble for.”

    So it, too, clarified its policy. While that was underway, local news reported that high school students found a teen passed out, with purple lips, in the bathroom of a McDonald’s down the street from their school, and used Narcan to revive them. It was during lunch on a school day.

    “We can’t Narcan our way out of the opioid use crisis,” said Kapunan. “But it was critical to do it first. Just like knowing 911.”

    Now, with the support of the district and county health department, students are training other students how to administer naloxone. Jackson Taylor, one of the student trainers, estimated they trained about 200 students over the course of three hours on a recent Saturday.

    “It felt amazing, this footstep toward fixing the issue,” Taylor said.

    Each trainee left with two doses of naloxone.

    This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 




    Kaiser Health NewsThis article was reprinted from khn.org, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – the independent source for health policy research, polling, and journalism.

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  • Spirulina shows promise in battling heart disease and diabetes

    Spirulina shows promise in battling heart disease and diabetes

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    In a recent study published in the journal Nutrients, a team of Italian researchers reviewed clinical and experimental findings from recent studies to understand the therapeutic contributions of Spirulina, also called blue-green cyanobacteria, in managing cardiovascular disease and its risk factors.

    Study: Beneficial Effects of Spirulina Supplementation in the Management of Cardiovascular Diseases. Image Credit: baibaz / ShutterstockStudy: Beneficial Effects of Spirulina Supplementation in the Management of Cardiovascular Diseases. Image Credit: baibaz / Shutterstock

    Background

    Although Spirulina has recently gained popularity as a ‘superfood’ because of its high nutritional content, the use of microalga in diet dates back to the ancient times of the Aztecs in Mexico. Spirulina is also known as blue-green cyanobacteria and are microscopic, photosynthesizing, filamentous microalgae of the genus Arthrospira, with A. plantensis and A. maxima being the two species most commonly used for their therapeutic and nutritional value.

    They grow in the tropics, in alkaline lakes with high bicarbonate and carbonate salt concentrations, although they have been known to survive in extremely cold temperatures. Spirulina is considered a ‘superfood’ because 60% to 70% of its dry weight is composed of protein, while it is also abundant in minerals, vitamins, carbohydrates, phycocyanin, carotenes, and fatty acids. As a nutraceutical, it has been added to various types of foods, including sports supplements and baby foods, while the pharmaceutical industry has popularized it in the form of capsules, dehydrated powders, and tablets.

    Therapeutic effects of Spirulina

    Research indicates that Spirulina exhibits a wide range of therapeutic effects such as anti-inflammatory, antidiabetic, antioxidant, hypolipidemic, and neuroprotective properties. The antioxidant properties are attributed mainly to the pigments phycocyanin, β-carotene, diatoxanthin, and diadinoxanthin found in Spirulina.

    Given its hypolipidemic and antioxidant properties, supplementation with Spirulina could be beneficial in lowering the risk of cardiovascular disease. Furthermore, diabetes, along with dyslipidemia and hypertension, is one of the risk factors for cardiovascular disease. Therefore, the present review examined how the cumulative health benefits of Spirulina could lower the overall risk of cardiovascular disease, which continues to be one of the major causes of mortality across the globe.

    Beneficial effects of Spirulina in CVDs.Beneficial effects of Spirulina in CVDs.

    Spirulina and hypertension

    The impact of Spirulina in lowering the risk of hypertension and stroke has been studied extensively in clinical trials, and the findings from these studies have shown that daily consumption of Spirulina, even added to foods such as salad dressing, significantly reduced the diastolic and systolic blood pressure.

    Consumption of Spirulina in the form of nutraceutical tablets also showed similar hypotensive results. Furthermore, animal studies using hypertensive rat models have shown that the high silicon content of Spirulina could be responsible for improving the elasticity of the arterial walls, along with angiotensin-converting enzyme-inhibiting properties that result in hypotensive effects.

    Antidiabetic effects of Spirulina

    Diabetes mellitus increases the risk of cardiovascular events such as heart failure, myocardial infarction, stroke, and peripheral vascular disease due to the micro- and macrovascular consequences of hyperglycemia. Cellular membrane integrity is also impacted by hyperglycemia, causing the peripheral tissues and liver to become insulin-resistant, increasing the generation of reactive oxygen species.

    In comparison to metformin, which is the standard treatment for hyperglycemia during diabetes, supplementation with Spirulina is believed to not only lower the levels of circulating glucose but also have a positive impact on lipid metabolism, which is linked to diabetes. The hypoglycemic and hypolipidemic properties of Spirulina are believed to have a cumulative effect in decreasing the risk of cardiovascular disease.

    The review discussed various clinical trials and studies using animal models of diabetes mellitus that have investigated the hypoglycemic properties of Spirulina and compared its efficacy in lowering blood sugar levels with that of metformin.

    While the mechanism through which Spirulina impacts blood glucose levels is not yet fully understood, the researchers believe that it could be influencing the secretion of insulin from the β-cells in the islets of Langerhans in the pancreas or further downstream, facilitating the transport of glucose from blood to all the peripheral tissue.

    Hyperlipidemia and Spirulina

    Spirulina has also demonstrated hypolipidemic properties by lowering the concentrations of low-density-lipoprotein cholesterol and triglycerides in the plasma while increasing the levels of high-density lipoprotein cholesterol, with the beneficial effects not being dose-dependent or toxic at high concentrations.

    Studies in animal models and overweight or obese human participants have reported significant benefits of Spirulina supplementation in lowering triglyceride levels, either as food additives or as nutraceutical pills or tablets. Spirulina was also found to be beneficial as an adjunct therapy to metformin in overweight diabetes patients.

    Conclusions

    Overall, this comprehensive review reported that consumption of Spirulina, either as an additive to regular foods or as a nutraceutical supplement, had numerous potential benefits, such as hypoglycemic, antioxidant, and hypolipidemic effects. However, the dosage and timing of Spirulina supplementation need to be standardized for optimal benefits in lowering the risk of cardiovascular disease.

    In conclusion, based on these data, more rigorous studies should be planned in the future aiming to address these critical questions, putting the foundations for developing a common guideline on “how and when” to use Spirulina.

    Journal reference:

    • Prete, V., Abate, A. C., Pietro, D., Lucia, D., Vecchione, C., & Carrizzo, A. (2024). Beneficial Effects of Spirulina Supplementation in the Management of Cardiovascular Diseases. Nutrients, 16(5). DOI: 10.3390/nu16050642, https://www.mdpi.com/2072-6643/16/5/642

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  • Understanding how stress accelerates cancer spread

    Understanding how stress accelerates cancer spread

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    Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery-;a challenge for cancer care.

    Xue-Yan He, a former postdoc in Cold Spring Harbor Laboratory (CSHL) Adjunct Professor Mikala Egeblad’s lab, says, “Stress is something we cannot really avoid in cancer patients. You can imagine if you are diagnosed, you cannot stop thinking about the disease or insurance or family. So it is very important to understand how stress works on us.”

    Now, He and Egeblad may have reached a breakthrough in understanding exactly that. Working with CSHL Professor Linda Van Aelst, they discovered that stress causes certain white blood cells called neutrophils to form sticky web-like structures that make body tissues more susceptible to metastasis. The finding could point to new treatment strategies that stop cancer’s spread before it starts.

    The team arrived at their discovery by mimicking chronic stress in mice with cancer. They first removed tumors that had been growing in mice’s breasts and spreading cancer cells to their lungs. Next, they exposed the mice to stress. What He observed was shocking. 

    She saw this scary increase in metastatic lesions in these animals. It was up to a fourfold increase in metastasis.” 

    Mikala Egeblad, Adjunct Professor, CSHL

    The team found that stress hormones called glucocorticoids acted on the neutrophils. These “stressed” neutrophils formed spider-web-like structures called NETs (neutrophil extracellular traps). NETs form when neutrophils expel DNA. Normally, they can defend us against invading microorganisms. However, in cancer, NETs create a metastasis-friendly environment.

    To confirm that stress triggers NET formation, leading to increased metastasis, He performed three tests. First, she removed neutrophils from the mice using antibodies. Next, she injected a NET-destroying drug into the animals. Lastly, she used mice whose neutrophils couldn’t respond to glucocorticoids. Each test achieved similar results. “The stressed mice no longer developed more metastasis,” He says.

    Notably, the team found that chronic stress caused NET formation to modify lung tissue even in mice without cancer. “It’s almost preparing your tissue for getting cancer,” Egeblad explains.

    To Van Aelst, the implication, though startling, is clear. “Reducing stress should be a component of cancer treatment and prevention,” she says.

    The team also speculates that future drugs preventing NET formation could benefit patients whose cancer hasn’t yet metastasized. Such new treatments could slow or stop cancer’s spread, offering much-needed relief.

    Source:

    Journal reference:

    He, X.-Y., et al. (2024). Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment. Cancer Cell. doi.org/10.1016/j.ccell.2024.01.013.

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  • CAR T cells target senescent cells, improve healthspan in mice

    CAR T cells target senescent cells, improve healthspan in mice

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    Chimeric antigen receptor (CAR) T cells have transformed the treatment of blood cancers in recent years. And there have been positive signs the “living drugs” can be harnessed against other diseases, like autoimmune disorders.

    Now laboratory research led by Memorial Sloan Kettering Cancer Center (MSK) and Cold Spring Harbor Laboratory suggests these engineered immune cells hold promise for treating some diseases related to aging, as well -; specifically, those caused by the accumulation of senescent cells (cells that stop dividing due to age or damage).

    An infusion of CAR T cells designed to target senescent cells was not only able to improve metabolic function in older mice and mice prematurely aged by a high-fat diet, but a single dose given to young, healthy mice also helped prevent metabolic decline later in life, according to findings the research team published in Nature Aging.

    When you hear ‘CAR T cell therapy,’ you think ‘cancer’ -; and it makes sense that it was pioneered at a place like MSK. But what we’re learning is that this approach of engineering immune cells to target disease has much broader possibilities.”


    Scott Lowe, PhD, senior study author, Chair of the Cancer Biology and Genetics Program in MSK’s Sloan Kettering Institute

    CAR T treatment improves metabolic function in mice

    In the study, younger mice were fed a high-fat diet for two months, which made them obese and caused metabolic stress. After an infusion of the experimental CAR T cells, the mice had lower body weight, better fasting blood glucose levels, and improved glucose and insulin tolerance, despite continuing the high-fat diet. They also had fewer senescent cells in the pancreas, liver, and fatty tissues than mice in a control group. Similar results were seen in older mice where metabolic function had decreased due to natural aging.

    Older mice that received the treatment even took longer to become exhausted when exercising. And the approach didn’t appear to cause any significant side effects.

    Further research is needed to see if the approach could extend the life span of the mice in addition to improving their “healthspan” -; that is, how long they stay healthy and free of disease, the scientists note.

    “We’re continuing to learn new things about senescence on a biological level,” Dr. Lowe says. “It will take time, but we’re interested in working with industry partners to move the laboratory findings into clinical trials.”

    There are a number of diseases associated with aging and chronic inflammation that potentially might be helped, Dr. Lowe says, such as chronic obstructive pulmonary disease (COPD), nonalcoholic steatohepatitis (NASH), osteoarthritis, metabolic syndrome, and even certain neurodegenerative diseases.

    Along with Dr. Lowe’s lab, immunologist Michel Sadelain, MD, PhD, and members of his lab were key collaborators in the research. Dr. Sadelain is a pioneer in the development of CAR T cell therapy, for which he was recently awarded the 2024 Breakthrough Prize in Life Sciences.

    The study was co-led by Inés Fernández-Maestre, a graduate student in the lab of MSK physician-scientist Ross Levine, MD, and by Corina Amor Vegas, MD, PhD, a former graduate student in the Lowe Lab who now heads her own lab at Cold Spring Harbor and is the corresponding author of the paper.

    Targeting senescent cells with CAR T

    A microscope image of an aged mouse liver showing signs of chronic inflammation (clusters of dark purple cells).

    Senescent cells are damaged cells that have gone into a protective, shutdown mode, where they stop dividing and actively send “help me” signals to the immune system. This can have some short-term benefits in contexts like wound healing and preventing the runaway cell division that happens in cancer, but it also can lead to chronic inflammation as senescent cells accumulate as people age.

    In 2020, researchers at MSK identified a molecule on the surface of senescent cells that was largely absent on other types of cells. This allowed them to design CAR T cells that could recognize and attack that specific molecule, called urokinase plasminogen activator receptor (uPAR). The team successfully tested the approach in several different mouse models of senescence-related diseases, including cancer and liver fibrosis, according to findings they published in Nature.

    The new research goes further in demonstrating that senolytic (senescence-targeting) cell therapies can improve symptoms associated with aging.

    The uPAR-targeting CAR T cells provide an alternative to the more traditional small-molecule drugs currently being investigated to clear senescent cells, notes Dr. Lowe, who is also a Howard Hughes Medical Institute Investigator.

    “One of the challenges with the current small-molecule drugs is that many don’t have a well-understood mechanism of action as it pertains to senescence. And a lot of them are repurposed cancer drugs with substantial toxicities.”

    Such drugs also must be given repeatedly.

    “T cells, however, have the ability to develop memory and persist in your body for really long periods, which is very different from a chemical drug,” notes Dr. Amor Vegas, who was also a co-first author on the earlier study. “With CAR T cells, you have the potential of getting this one treatment, and then that’s it. For chronic pathologies, that’s a huge advantage. Think about patients who need treatment multiple times per day versus you get an infusion, and then you’re good to go for multiple years.”

    Furthermore, with a cellular therapy, it’s possible to engineer in safety features to mitigate side effects as well as simultaneously to target multiple molecules on the surface of cells -; reducing the chances of them attacking healthy cells.

    Different challenges than using CAR T cell against cancer

    Through these experiments, the research team was able to show: uPAR-positive cells increase with age and significantly contribute to aging-related disfunction in tissues; uPAR-targeting CAR T cells can effectively eliminate the senescent cells without major side effects in mice; and that administering the treatment improved metabolism health in both normal aging and diet-related metabolic disease.

    Mice normally live about two years, and research found the uPAR-targeting CAR T cells persisted and expanded for more than 15 months in mice as they grew from youth into older age.

    “In some ways, using CAR T cells to treat age-associated diseases presents distinct challenges from using these therapies in cancer,” Dr. Lowe says. “If only a few cancer cells survive treatment, they may keep dividing to enable the tumor to relapse. Since senescent cells don’t divide, clearing most but not all of them should still produce substantial health benefits.”

    Still, there is a high safety bar for developing therapies for diseases that are less lethal than cancer.

    “We continue to develop new strategies to engineer cell therapies to be less toxic and less expensive,” Dr. Sadelain says. “These efforts will undoubtedly expand the list of diseases that can be treated by CAR T cell therapies in the coming years.”

    Source:

    Journal reference:

    Amor, C., et al. (2024). Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nature Aging. doi.org/10.1038/s43587-023-00560-5.

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