Kondrakiewicz, K., Kostecki, M., Szadzinska, W. & Knapska, E. Ecological validity of social interaction tests in rats and mice. Genes Brain Behav. 18, e12525 (2019).
Article
PubMed
Google Scholar
Olsson, A., Knapska, E. & Lindstrom, B. The neural and computational systems of social learning. Nat. Rev. Neurosci. 21, 197–212 (2020).
Article
CAS
PubMed
Google Scholar
Burgos-Robles, A., Gothard, K. M., Monfils, M. H., Morozov, A. & Vicentic, A. Conserved features of anterior cingulate networks support observational learning across species. Neurosci. Biobehav. Rev. 107, 215–228 (2019).
Article
PubMed
PubMed Central
Google Scholar
Keum, S. & Shin, H. S. Rodent models for studying empathy. Neurobiol. Learn. Mem. 135, 22–26 (2016).
Article
PubMed
Google Scholar
Blanchard, D. C., Griebel, G., Pobbe, R. & Blanchard, R. J. Risk assessment as an evolved threat detection and analysis process. Neurosci. Biobehav. Rev. 35, 991–998 (2011).
Article
PubMed
Google Scholar
Qi, S. et al. How cognitive and reactive fear circuits optimize escape decisions in humans. Proc. Natl Acad. Sci. USA 115, 3186–3191 (2018).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Fanselow, M. S. Neural organization of the defensive behavior system responsible for fear. Psychon. Bull. Rev. 1, 429–438 (1994).
Article
CAS
PubMed
Google Scholar
LeDoux, J. E. & Pine, D. S. Using neuroscience to help understand fear and anxiety: a two-system framework. Am. J. Psychiatry 173, 1083–1093 (2016).
Article
PubMed
Google Scholar
Jercog, D. et al. Dynamical prefrontal population coding during defensive behaviours. Nature 595, 690–694 (2021).
Article
ADS
CAS
PubMed
Google Scholar
Mobbs, D. The ethological deconstruction of fear(s). Curr. Opin. Behav. Sci. 24, 32–37 (2018).
Article
PubMed
PubMed Central
Google Scholar
Sharpe, M. J. & Killcross, S. Modulation of attention and action in the medial prefrontal cortex of rats. Psychol. Rev. 125, 822–843 (2018).
Article
PubMed
Google Scholar
DSM-5. Diagnostic and Statistical Manual of Mental Disorders, 4th edn (APA Press, 2013).
Kim, A., Keum, S. & Shin, H. S. Observational fear behavior in rodents as a model for empathy. Genes Brain Behav. 18, e12521 (2019).
Article
PubMed
Google Scholar
Preston, S. D. & de Waal, F. B. Empathy: its ultimate and proximate bases. Behav. Brain Sci. 25, 1–20 (2002).
Article
PubMed
Google Scholar
Cummings, K. A. & Clem, R. L. Prefrontal somatostatin interneurons encode fear memory. Nat. Neurosci. 23, 61–74 (2020).
Article
CAS
PubMed
Google Scholar
Yizhar, O. & Levy, D. R. The social dilemma: prefrontal control of mammalian sociability. Curr. Opin. Neurobiol. 68, 67–75 (2021).
Article
CAS
PubMed
Google Scholar
Chen, P. & Hong, W. Neural circuit mechanisms of social behavior. Neuron 98, 16–30 (2018).
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang, B. et al. Distinct and dynamic ON and OFF neural ensembles in the prefrontal cortex code social exploration. Neuron 100, 700–714.e709 (2018).
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu, Y. E. et al. Neural control of affiliative touch in prosocial interaction. Nature 599, 262–267 (2021).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Padilla-Coreano, N. et al. Cortical ensembles orchestrate social competition through hypothalamic outputs. Nature 603, 667–671 (2022).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Ito, W., Palmer, A. J. & Morozov, A. Social synchronization of conditioned fear in mice requires ventral hippocampus input to the amygdala. Biol. Psychiatry 93, 322–330 (2023).
Article
PubMed
Google Scholar
Scheggia, D. et al. Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice. Nat. Neurosci. 23, 47–60 (2020).
Article
CAS
PubMed
Google Scholar
Piva, M. et al. The dorsomedial prefrontal cortex computes task-invariant relative subjective value for self and other. eLife 8, e44939 (2019).
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang, F. et al. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science 334, 693–697 (2011).
Article
ADS
CAS
PubMed
Google Scholar
Murugan, M. et al. Combined social and spatial coding in a descending projection from the prefrontal cortex. Cell 171, 1663–1677.e1616 (2017).
Article
CAS
PubMed
PubMed Central
Google Scholar
Yusufishaq, S. & Rosenkranz, J. A. Post-weaning social isolation impairs observational fear conditioning. Behav. Brain Res. 242, 142–149 (2013).
Article
PubMed
PubMed Central
Google Scholar
Allsop, S. A. et al. Corticoamygdala transfer of socially derived information gates observational learning. Cell 173, 1329–1342.e1318 (2018).
Article
CAS
PubMed
PubMed Central
Google Scholar
Jeon, D. et al. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat. Neurosci. 13, 482–488 (2010).
Article
CAS
PubMed
PubMed Central
Google Scholar
Keum, S. & Shin, H. S. Neural basis of observational fear learning: a potential model of affective empathy. Neuron 104, 78–86 (2019).
Article
CAS
PubMed
Google Scholar
Paradiso, E., Gazzola, V. & Keysers, C. Neural mechanisms necessary for empathy-related phenomena across species. Curr. Opin. Neurobiol. 68, 107–115 (2021).
Article
CAS
PubMed
Google Scholar
Smith, M. L., Asada, N. & Malenka, R. C. Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia. Science 371, 153–159 (2021).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Fillinger, C., Yalcin, I., Barrot, M. & Veinante, P. Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24a′ and 24b′ in the mouse. Brain Struct. Funct. 223, 1747–1778 (2018).
PubMed
Google Scholar
Sierra-Mercado, D., Padilla-Coreano, N. & Quirk, G. J. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36, 529–538 (2011).
Article
PubMed
Google Scholar
Halladay, L. R. & Blair, H. T. Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation vs. inhibition of movement. J Neurophysiol. 114, 793–807 (2015).
Article
CAS
PubMed
PubMed Central
Google Scholar
Padilla-Coreano, N., Tye, K. M. & Zelikowsky, M. Dynamic influences on the neural encoding of social valence. Nat. Rev. Neurosci. 23, 535–550 (2022).
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang, Z. et al. Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice. Nat. Commun. 14, 3458 (2023).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Franklin, T. B. et al. Prefrontal cortical control of a brainstem social behavior circuit. Nat. Neurosci. 20, 260–270 (2017).
Article
CAS
PubMed
PubMed Central
Google Scholar
Siciliano, C. A. et al. A cortical–brainstem circuit predicts and governs compulsive alcohol drinking. Science 366, 1008–1012 (2019).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Vander Weele, C. M. et al. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature 563, 397–401 (2018).
Article
ADS
Google Scholar
Assareh, N., Bagley, E. E., Carrive, P. & McNally, G. P. Brief optogenetic inhibition of rat lateral or ventrolateral periaqueductal gray augments the acquisition of Pavlovian fear conditioning. Behav. Neurosci. 131, 454–459 (2017).
Article
PubMed
Google Scholar
Courtin, J. et al. Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression. Nature 505, 92–96 (2014).
Article
ADS
PubMed
Google Scholar
Ozawa, T. et al. A feedback neural circuit for calibrating aversive memory strength. Nat. Neurosci. 20, 90–97 (2017).
Article
CAS
PubMed
Google Scholar
Haaker, J., Yi, J., Petrovic, P. & Olsson, A. Endogenous opioids regulate social threat learning in humans. Nat. Commun. 8, 15495 (2017).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
Huang, J. et al. A neuronal circuit for activating descending modulation of neuropathic pain. Nat. Neurosci. 22, 1659–1668 (2019).
Article
CAS
PubMed
Google Scholar
Rozeske, R. R. et al. Prefrontal–periaqueductal gray-projecting neurons mediate context fear discrimination. Neuron 97, 898–910.e896 (2018).
Article
CAS
PubMed
Google Scholar
Anastasiades, P. G., Marlin, J. J. & Carter, A. G. Cell-type specificity of callosally evoked excitation and feedforward inhibition in the prefrontal cortex. Cell Rep. 22, 679–692 (2018).
Article
CAS
PubMed
PubMed Central
Google Scholar
Senn, V. et al. Long-range connectivity defines behavioral specificity of amygdala neurons. Neuron 81, 428–437 (2014).
Article
CAS
PubMed
Google Scholar
Sotres-Bayon, F., Sierra-Mercado, D., Pardilla-Delgado, E. & Quirk, G. J. Gating of fear in prelimbic cortex by hippocampal and amygdala inputs. Neuron 76, 804–812 (2012).
Article
CAS
PubMed
PubMed Central
Google Scholar
Hagihara, K. M. et al. Intercalated amygdala clusters orchestrate a switch in fear state. Nature 594, 403–407 (2021).
Article
ADS
CAS
PubMed
PubMed Central
Google Scholar
McGarry, L. M. & Carter, A. G. Inhibitory gating of basolateral amygdala inputs to the prefrontal cortex. J. Neurosci. 36, 9391–9406 (2016).
Article
CAS
PubMed
PubMed Central
Google Scholar
Anderson, S. W., Bechara, A., Damasio, H., Tranel, D. & Damasio, A. R. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat. Neurosci. 2, 1032–1037 (1999).
Article
CAS
PubMed
Google Scholar
Shin, L. M., Rauch, S. L. & Pitman, R. K. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann. NY Acad. Sci. 1071, 67–79 (2006).
Article
ADS
PubMed
Google Scholar
Jeon, D. & Shin, H. S. in Current Protocols in Neuroscience (eds. Crawley, J. N. et al.) Ch. 8, Unit 8 27 (2011).
Holmes, A. & Rodgers, R. J. Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine. Eur. J. Pharmacol. 459, 221–230 (2003).
Article
CAS
PubMed
Google Scholar
Karlsson, R. M., Tanaka, K., Heilig, M. & Holmes, A. Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist. Biol. Psychiatry 64, 810–814 (2008).
Article
CAS
PubMed
PubMed Central
Google Scholar
Feyder, M. et al. Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams’ syndrome. Am. J. Psychiatry 167, 1508–1517 (2010).
Article
PubMed
PubMed Central
Google Scholar
Gunduz-Cinar, O. et al. A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction. Neuron 111, 3053–-3067.e10 (2023).
Article
CAS
PubMed
Google Scholar
Halladay, L. R. et al. Prefrontal regulation of punished ethanol self-administration. Biol. Psychiatry 87, 967–978 (2020).
Article
CAS
PubMed
Google Scholar
Eastwood, B. S. et al. Whole mouse brain reconstruction and registration to a reference atlas with standard histochemical processing of coronal sections. J. Comp. Neurol. 527, 2170–2178 (2019).
Article
PubMed
PubMed Central
Google Scholar
Ahrlund-Richter, S. et al. A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse. Nat. Neurosci. 22, 657–668 (2019).
Article
PubMed
Google Scholar
Sengupta, A. & Holmes, A. A discrete dorsal raphe to basal amygdala 5-HT circuit calibrates aversive memory. Neuron 103, 489–505.e487 (2019).
Article
CAS
PubMed
PubMed Central
Google Scholar