Browsing Tag
Immunotherapy
35 posts
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Samples from paediatric patients with ALL and HDs The current study is a secondary investigation using patient samples…
Engineered CD47 protects T cells for enhanced antitumour immunity
Cell lines The Nalm6 B-ALL cell line was provided by D. Barrett and retrovirally transduced to express GFP…
HEROS 2.0 trial results published
Researchers at Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor College of…
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Mice All mice used in this study were on a C57BL/6J genetic background and purchased from the Jackson…
Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer…
Study identifies potential strategy to diminish the devastating impacts of traumatic brain injuries
For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely.…
New research pinpoints key pathways in prostate cancer’s vulnerability to ferroptosis
In a recent review published in the journal Nature Reviews Urology, researchers examined the molecular mechanisms and metabolic…
Insilico Medicine’s AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy
In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances. But…
Tumor microbiomes offer new insights for enhancing cancer therapies
In a recent study published in the journal Cell, researchers used metagenomics, genomics, and transcriptomics to examine microbiome…
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Ethical approval statement This research and all study protocols have been approved and comply with the Peter MacCallum…