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Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.
Join us on a journey where chemistry meets creativity, and the wonders of science unfold. Quench your intellectual thirst with thought-provoking articles that transcend the boundaries of conventional knowledge.

Reply to: Artefacts in single-cell mtDNA analyses misinform phylogenies

Reply to: Artefacts in single-cell mtDNA analyses misinform phylogenies Reply to: Artefacts in single-cell mtDNA analyses misinform phylogenies


  • Lareau, C. A., Chapman, M. S., Penter, L., Nawy, T. & Pe’er, D. Artefacts in single-cell mtDNA analyses misinform phylogenies. Nature https://doi.org/10.1038/s41586-026-10777-0 (2026).

    Article 
    PubMed 

    Google Scholar
     

  • Weng, C. et al. Deciphering cell states and genealogies of human hematopoiesis. Nature 627, 389–398 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Salk, J. J., Schmitt, M. W. & Loeb, L. A. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations. Nat. Rev. Genet. 19, 269–285 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bae, J. H. et al. Single duplex DNA sequencing with CODEC detects mutations with high sensitivity. Nat. Genet. 55, 871–879 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schmitt, M. W. et al. Detection of ultra-rare mutations by next-generation sequencing. Proc. Natl Acad. Sci. USA 109, 14508–14513 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weng, C., Weissman, J. S. & Sankaran, V. G. Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profiling. Preprint at bioRxiv https://doi.org/10.1101/2024.08.23.609473 (2024).

  • Rausser, S. et al. Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. eLife 10, e70899 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ju, Y. S. et al. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. eLife 3, e02935 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weng, C. et al. Deciphering cell states and genealogies of human haematopoiesis. Nature 627, 389–398 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mitchell, E. et al. Clonal dynamics of haematopoiesis across the human lifespan. Nature 606, 343–350 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, X. et al. Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells. Genome Biol. 26, 70 (2025).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • An, J. et al. Mitochondrial DNA mosaicism in normal human somatic cells. Nat. Genet. 56, 1665–1677 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Árnadóttir, E. R. et al. The rate and nature of mitochondrial DNA mutations in human pedigrees. Cell 187, 3904–3918.e8 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • Sashittal, P., Chen, V., Pasarkar, A. & Raphael, B. J. Joint inference of cell lineage and mitochondrial evolution from single-cell sequencing data. Bioinformatics 40, i218–i227 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cossa, A. et al. MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omics. Nat. Commun. https://doi.org/10.1038/s41467-026-71607-5 (2026).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kozlov, A., Alves, J. M., Stamatakis, A. & Posada, D. CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data. Genome Biol. 23, 37 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



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