Browsing Tag
Cancer genomics
16 posts
Normal breast tissues harbour rare populations of aneuploid epithelial cells
Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486,…
Origins and impact of extrachromosomal DNA
Dataset GEL is a company funded by the Department of Health and Social Care in the UK. Part…
Clonal dynamics after allogeneic haematopoietic cell transplantation
Study population Ten donor–recipient pairs were selected from the original 45 HCT recipients and HLA-matched sibling donors who…
Polyclonal-to-monoclonal transition in colorectal precancerous evolution
Curtius, K., Wright, N. A. & Graham, T. A. Evolution of premalignant disease. Cold Spring Harb. Perspect. Med.…
Tumour evolution and microenvironment interactions in 2D and 3D space
Experimental methods Specimens and sample processing All samples were collected with informed consent at the Washington University School…
The genomic landscape of 2,023 colorectal cancers
Sample collection The following steps were taken for sample collection. (1) Ethics approval was provided to the 100kGP…
Prognostic genome and transcriptome signatures in colorectal cancers
Patient cohort Patients diagnosed with CRC between 2004 and 2019, at Uppsala University Hospital or Umeå University Hospital,…
DNA mismatch and damage patterns revealed by single-molecule sequencing
Mustjoki, S. & Young, N. S. Somatic mutations in “benign” disease. N. Engl. J. Med. 384, 2039–2052 (2021).…
Strand-resolved mutagenicity of DNA damage and repair
Genomic annotation The C3H/HeJ mouse strain reference genome assembly C3H_HeJ_v1 (ref. 58) was used for read mapping, annotation…
Mapping genotypes to chromatin accessibility profiles in single cells
Corces, M. R. et al. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution. Nat. Genet.…