Browsing Tag
Cancer Immunotherapy
13 posts
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers
Mlecnik, B. et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival…
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Human subjects The Stanford Institutional Review Board approved this trial, which was registered with ClinicalTrials.gov (NCT04196413). Informed patient…
Immune responses in checkpoint myocarditis across heart, blood and tumour
Haslam, A. & Prasad, V. Estimation of the percentage of US patients with cancer who are eligible for…
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Samples from paediatric patients with ALL and HDs The current study is a secondary investigation using patient samples…
Selective haematological cancer eradication with preserved haematopoiesis
Structural dataset and computational analysis The experimentally determined 3D structure of the CD45 extracellular domain was retrieved from…
Engineered CD47 protects T cells for enhanced antitumour immunity
Cell lines The Nalm6 B-ALL cell line was provided by D. Barrett and retrovirally transduced to express GFP…
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Tumour samples Tumour samples were collected from individuals with melanoma, non–small cell lung cancer, ovarian cancer, and breast…
Insilico Medicine’s AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy
In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances. But…
FOXO1 is a master regulator of memory programming in CAR T cells
Primary human T cells For experiments completed at Stanford, buffy coats from anonymous, consenting healthy donors were obtained…
Therapeutic potential of CD20 x CD3 bispecific antibodies
On Monday, March 25th, 2024, the U.S. FDA declined approval for Regeneron’s Odronextamab for two forms of lymphoma…