Browsing Tag
Chemical tools
5 posts
Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis
Felnagle, E. A. et al. Nonribosomal peptide synthetases involved in the production of medically relevant natural products. Mol.…
Synthetic GPCRs for programmable sensing and control of cell behaviour
Plasmid constructs and cloning Constructs used for transient expression in HEK293T cells were cloned into the pAAV viral…
Targeted protein relocalization via protein transport coupling
Kau, T. R., Way, J. C. & Silver, P. A. Nuclear transport and cancer: from mechanism to intervention.…
Oxidative cyclization reagents reveal tryptophan cation–π interactions
Spicer, C. D. & Davis, B. G. Selective chemical protein modification. Nat. Commun. 5, 4740–4753 (2014). Article ADS …
Targeted protein degradation via intramolecular bivalent glues
Chemical synthesis Additional details are provided in the Supplementary Methods. Plasmids and oligonucleotides The design and construction of the…