Browsing Tag
Functional genomics
6 posts
Identification and genetic dissection of convergent persister cell states
Bacterial strains and culture conditions E. coli MG1655, UPEC CFT073, and derivative mutant strains (Supplementary Table 6) were…
Deciphering the impact of genomic variation on function
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA Jesse M. Engreitz, Benjamin C. Hitz, Anshul Kundaje, Andreas R.…
A disease-associated gene desert directs macrophage inflammation through ETS2
Analysis of existing data relating to chr21q22 IBD GWAS summary statistics3 were used to perform multiple causal variant…
Emx2 underlies the development and evolution of marsupial gliding membranes
The P. breviceps sugar glider breeding colony All experiments performed were approved by the IACUC committee at Princeton…
Improving prime editing with an endogenous small RNA-binding protein
General methods CRISPRi sgRNAs were cloned into pU6-sgRNA EF1Alpha-puro-T2A-BFP (Addgene, 60955)13 as described in https://weissman.wi.mit.edu/resources/sgRNACloningProtocol.pdf (Supplementary Table 4).…
Convergence of coronary artery disease genes onto endothelial cell programs
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Primers 1, 59 (2021). Article CAS Google Scholar …