Browsing Tag
Gene regulation
7 posts
Exaptation of ancestral cell-identity networks enables C4 photosynthesis
Plant growth For the de-etiolation time course, seeds of Oryza sativa spp. japonica cultivar Kitaake and Sorghum bicolor…
Single-molecule states link transcription factor binding to gene expression
Spitz, F. & Furlong, E. E. M. Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet.…
Machine-guided design of cell-type-targeting cis-regulatory elements
Training Malinois, a model of MPRA activity of CREs To enable systematic evaluation of parameters governing data preprocessing,…
Single-cell nascent RNA sequencing unveils coordinated global transcription
scGRO–seq conceptualization Capturing nascent RNA with sufficient efficiency from single cells for meaningful analysis was deemed challenging. However,…
Molecular basis for differential Igk versus Igh V(D)J joining mechanisms
Experimental procedures Statistical methods were not used to predetermine sample size. Experiments were not randomized. Investigators were not…
Selfish conflict underlies RNA-mediated parent-of-origin effects
Maintenance of worm strains Nematodes were grown on modified nematode growth medium (NGM) plates with 1% agar/0.7% agarose…
Convergence of coronary artery disease genes onto endothelial cell programs
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Primers 1, 59 (2021). Article CAS Google Scholar …