Browsing Tag
Genome-wide association studies
6 posts
Genetic links between ovarian ageing, cancer risk and de novo mutation rates
UK Biobank data processing and quality control To conduct the rare variant burden analyses described in this study,…
September 11, 2024
Genetic drivers and cellular selection of female mosaic X chromosome loss
Machiela, M. J. et al. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.…
June 12, 2024
Refining the impact of genetic evidence on clinical success
Definition of metrics Except where otherwise noted, we define genetic support of a drug mechanism (that is, a…
April 17, 2024
Genome-wide characterization of circulating metabolic biomarkers
NMR metabolomics In this work, we expand our previous GWAS of 123 human metabolic traits in ~25,000 individuals4…
March 6, 2024
Genomic data in the All of Us Research Program
The All of Us cohort All of Us aims to engage a longitudinal cohort of one million or…
February 19, 2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University…
February 19, 2024