Browsing Tag
Microglia
11 posts
Diet’s impact on gut bacteria offers new clues in Parkinson’s disease management
A recent Npj Parkinson’s Disease study investigates the association between diet and gut microbiome composition in an effort to…
Exploring the versatile roles of tissue macrophages beyond immune defense
A recent study published in Science Immunology summarized the role of resident tissue macrophages (RTMs) in homeostasis and…
Ketamine’s rapid impact on depression linked to immune system pathways
In a recent study published in Molecular Psychiatry, researchers review the anti-inflammatory effects of ketamine in the peripheral and…
Xenotransplantation model used for studying microglial response to Alzheimer’s disease
Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute…
Minocycline fails to slow vision loss in people with dry age-related macular degeneration
The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic…
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Single-nucleus RNA sequencing of human brain tissue Frozen superior frontal gyrus and fusiform gyrus tissue blocks and pathology…
Mitochondrial complex I activity in microglia sustains neuroinflammation
Mice and EAE The Cx3cr1-YFPcreERT2R26tdTomato fate mapping mouse was generated by crossing B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT2)Litt/WganJ52 with B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J)53, as previously described19,20.…
How cell types and location influence Parkinson’s disease
In a recent study published in Cell Reports, researchers conducted a single-cell spatial transcriptome analysis on murine brain…
Study pinpoints APOE4’s harmful effect on lipids
UNC School of Medicine researcher Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen…
Enzyme released by immune cells may play role in depression
Mount Sinai researchers have shown for the first time that immune cells called monocytes, derived in the bone…