Tag: Pandemic

  • Understanding risks and prevention strategies

    Understanding risks and prevention strategies

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    In a recent scientific report published in the European Food Safety Authority (EFSA) journal, a large team of researchers from the EFSA and European Centre for Disease Prevention and Control (ECDC) discussed the intrinsic and extrinsic drivers for a potential pandemic due to evolved avian influenza viruses, and risk mitigation measures that are part of the One Health approach.

    Report: Drivers for a pandemic due to avian influenza and options for One Health mitigation measures. Image Credit: Pordee_Aomboon / ShutterstockReport: Drivers for a pandemic due to avian influenza and options for One Health mitigation measures. Image Credit: Pordee_Aomboon / Shutterstock

    Current avian influenza virus status

    Wild bird populations in the European Economic Area (EEA) and the European Union (EU) are known to have a high prevalence of avian influenza viruses that cause significant disease and mortality. Outbreaks have also been reported from fur animal farms, where the avian influenza viruses are thought to have been transmitted from birds to mammals. These infections among fur animals are believed to be due to transmission of the virus from birds to various mammalian species and possibly also because of transmission between mammalian species.

    Although cases of transmission of these viruses from birds to humans have not been widely reported, the evolution of avian influenza viruses and the dispersal of the virus through migratory wild birds could result in the selection of viruses that can infect humans.

    Given that humans do not yet have robust immune defenses against avian influenza viruses, the emergence of a virus capable of infecting and rapidly spreading among humans poses the risk of a potential pandemic. Examining the intrinsic and extrinsic drivers that can facilitate the evolution of avian influenza viruses to infect humans and to develop effective mitigation measures is imperative.

    Intrinsic and extrinsic drivers of viral evolution

    Factors such as susceptibility of the host and viral characteristics, known as intrinsic drivers, and extrinsic drivers, such as environmental factors, human activities, and climate, can facilitate the emergence of avian influenza viruses that carry mutations that allow them to infect mammals.

    Viral characteristics such as the reassortment propensity can drive the avian influenza virus to adapt to mammalian hosts. The hemagglutinin 5 neuraminidase 1 (H5N1) or avian influenza A virus, which contains the 2.3.4.4b clade that is currently circulating, has displayed evolutionary changes that could allow it to infect mammals and reassort. Furthermore, the global prevalence of the H5N1 virus in birds, including heterogenous poultry livestock, could result in the accumulation of various mutations that enable the virus to infect mammals, especially humans.

    Reassortment can also lead to rapid genetic shifts that allow the virus to infect and replicate in humans and transmit among human populations. Coinfection of mammals with seasonal influenza and avian influenza virus could also increase the probability of reassortment events.

    Furthermore, fur animals such as foxes and minks are highly susceptible to influenza viruses, and the exposure of these mammals to highly pathogenic strains of the avian influenza virus through contaminated feed could drive the virus’s adaptation to mammals. Outdoor production farms and those with proximity to areas rich in water birds provide more opportunities for the virus to be introduced into farms. Peri-urban and synanthropic wild animals could also facilitate the spread of the virus from wild birds to humans and animals.

    Habitat destruction, extreme climatic events, and weather conditions can also impact the demography and ecology of these wild bird populations, acting as extrinsic drivers of the evolution of the avian influenza virus.

    Mitigation measures

    Risk mitigation measures included in the One Health approach suggested surveillance among target animal and human populations along with the generation and sharing of genomic data. Target animals included wild and captive birds, poultry, susceptible domestic mammals such as fur animals, cats, pigs, and peri-domestic and peri-urban mammals.

    The measures also comprised development and access to sustainable, rapid diagnostic methods using genomic data to screen for avian influenza virus in relevant populations. An additional critical area for risk mitigation was occupational safety in areas where humans interact closely with target animals. Furthermore, reassortment risk can be reduced by vaccinating individuals with a higher probability of occupational exposure to avian influenza against the seasonal influenza virus.

    The scientific report also discussed other areas, such as improving the veterinary infrastructure, biosecurity, communicating the risk to various audiences, and vaccinating animals, which could help mitigate the risk of the avian influenza virus adapting to humans and animals.

    Conclusions

    In summary, this report by the EFSA provided a detailed discussion of various intrinsic and extrinsic drivers, such as viral characteristics, factors that increase the susceptibility of animals, and environmental factors that could accelerate the adaptation of avian influenza viruses to mammalian hosts. The scientists also expanded on various mitigation measures, at individual and community levels, that could be followed to reduce the risk of adaptation and transmission of the avian influenza virus among animal and human populations.

    Journal reference:

    • European Food Safety Authority (EFSA), European Centre for Disease Prevention and Control (ECDC), C., Adlhoch, C., Alm, E., Enkirch, T., Lamb, F., … Broglia, A. (2024). Drivers for a pandemic due to avian influenza and options for One Health mitigation measures. EFSA Journal, 22(4), e8735. DOI: 10.2903/j.efsa.2024.8735, https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2024.8735

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  • COVID-19 shatters decades of global health progress, slashing life expectancy

    COVID-19 shatters decades of global health progress, slashing life expectancy

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    A recent study published in The Lancet presented the global burden of 288 mortality causes and life expectancy decomposition.

    The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has been analyzing causes of human death for over three decades, which has been used to guide policies, monitor/assess health interventions, and reduce risk factors. Assessing cause-specific mortality trends helps inform health policies, which must evolve to account for changes in the global health landscape.

    Mortality patterns evolve continually as some areas succeed in reduction efforts while other causes linger in specific locations. Further, there have been improvements in several causes of death in the past three decades, some of which have substantially narrowed geographically and are concentrated in smaller areas.

    Study: Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Image Credit: tomertu / ShutterstockStudy: Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Image Credit: tomertu / Shutterstock

    About the study

    In the present study, researchers presented mortality concentrations and life expectancy decomposition. GBD 2021 provided a comprehensive set of the fatal disease burden for 288 causes by sex and age in 204 countries and territories between 1990 and 2021, an update from previous estimates for 1990–2019. The team calculated years of life lost (YLLs) as the product of death count for each cause, age, sex, year, and location, as well as standard life expectancy at each age.

    Cause-specific mortality rates were computed using the causes of death ensemble model for most causes, and alternative strategies were applied to model causes with unusual epidemiology or insufficient data. Diseases and injuries were classified into four levels, with both non-fatal and fatal causes. Level 1 causes included three broad aggregate categories: 1) non-communicable diseases (NCDs), 2) communicable, maternal, neonatal, and nutritional (CMNN) diseases, and 3) injuries.

    Level 2 disaggregated these categories into 22 clusters, which were further disaggregated into levels 3 and 4 causes. Life expectancy was decomposed by cause of death, year, and location to explore cause-specific effects on life expectancy between 1990 and 2021. Concentrated causes were estimated using the coefficient of variation and mortality concentration (the fraction of the population affected by 90% of deaths).

    Global choropleth maps of COVID-19 (A) and OPRM (B) for 2021 that show sub-national detail where available.

    Global choropleth maps of COVID-19 (A) and OPRM (B) for 2021 that show sub-national detail where available. OPRM=other pandemic-related mortality.

    Findings

    During 1990–2019, the annual rate of change in all-cause global mortality ranged between -0.9% and 2.4%. The corresponding rate in age-standardized deaths ranged between -3.3 and 0.4%. Nevertheless, deaths increased by 10.8% worldwide in 2020 compared to 2019. This persisted in 2021, with a 7.5% increase relative to 2020. Likewise, the age-standardized mortality rate showed a similar pattern, increasing 8.1% in 2020 and 5.2% in 2021.

    Each row represents the change in life expectancy from 1990 to 2021 for a given GBD region. A bar to the right of 0 represents an increase in life expectancy due to changes in the given cause, and a bar to the left of 0 represents a decrease in life expectancy for a given cause. For readability, labels indicating a change in life expectancy of less than 0·3 years are not shown.

    Each row represents the change in life expectancy from 1990 to 2021 for a given GBD region. A bar to the right of 0 represents an increase in life expectancy due to changes in the given cause, and a bar to the left of 0 represents a decrease in life expectancy for a given cause. For readability, labels indicating a change in life expectancy of less than 0·3 years are not shown. CKD=chronic kidney disease. COPD=chronic obstructive pulmonary disease. GBD=Global Burden of Diseases, Injuries, and Risk Factors Study. LRI=lower respiratory infection. NCD=non-communicable disease. OPRM=other pandemic-related mortality. *Does not include war and terrorism. †Does not include natural disasters.

    In 2020-21, coronavirus disease 2019 (COVID-19) deaths and other pandemic-related mortality (OPRM) altered mortality patterns for the leading causes of age-standardized death. At level 3, the rankings of the four mortality causes (1. ischemic heart disease, 2. stroke, 3. chronic obstructive pulmonary disease, and 4. lower respiratory infections) with the highest age-standardized rates in 2019 were the same as in 1990.

    However, in 2021, stroke became the third leading cause of age-standardized mortality, as COVID-19 eclipsed it as the second leading cause. Besides, OPRM was the fifth leading cause, whereas lower respiratory infections became the seventh leading cause. Although the impact of COVID-19 on age-standardized mortality was similar to that of common obstructive pulmonary disease in 2020, it increased by 60.2% in 2021.

    Around 4.8 million and 7.89 million deaths occurred worldwide due to COVID-19 in 2020 and 2021, respectively. Age-standardized rates varied highly among GBD super-regions, with the highest in sub-Saharan Africa and the lowest in Southeast and East Asia and Oceania. OPRM and COVID-19 deaths also varied substantially by age, with older age groups being disproportionately affected.

    In 1990, the three leading causes of YLLs globally were CMNN diseases. Further, neonatal disorders remained the leading cause in 2019, but NCDs, viz., ischemic heart disease and stroke, replaced the second and third leading causes, respectively. However, COVID-19 was the second leading cause of YLLs in 2021, with neonatal disorders and ischemic heart disease ranking first and third, respectively.

    There have been long-standing positive trends in global life expectancy since the 1990s. Overall, life expectancy increased by 7.8 years between 1990 and 2019. However, during 2019-21, it decreased by 2.2 years due to COVID-19 and OPRM. Despite this decline, there was an overall increase of 6.2 years throughout the study period.

    The decrease in mortality from enteric infections (paratyphoid, typhoid, and diarrheal diseases) affected the increase in global life expectancy. The reduction in deaths due to lower respiratory infection had the second most significant impact. All seven super-regions had an increase in life expectancy from 1990 to 2021.

    Southeast and East Asia and Oceania had the highest gain (8.3 years), mainly due to lower mortality from chronic respiratory diseases. South Asia had the second largest gain (7.8 years) in life expectancy, mainly due to decreased mortality from enteric infections. Notably, Latin America and the Caribbean superregion had the largest decline in life expectancy (3.6 years) due to COVID-19.

    The decline in mortality due to enteric disease substantially impacted global life expectancy. Mortality concentration emerged as 160 countries/territories made progress in CMNN disease mortality. Deaths were more concentrated in some regions or countries. For instance, 90% of deaths due to enteric infections in areas with 63% of the population of children under five years in 1990 reduced to areas with 51% of the population in 2021.

    Further, the reduction in lower respiratory infections positively affected life expectancy in regions such as eastern and western sub-Saharan Africa and Andean Latin America. Moreover, reductions in stroke increased life expectancy by 0.8 years. However, stroke deaths were not concentrated. Overall, NCDs did not show a mortality concentration at large.

    Conclusions

    In sum, the present analysis offered insights into the global disease landscape before and during the two years of the COVID-19 pandemic. The findings showed that, after three decades of life expectancy improvements and reductions in age-standardized mortality rates, COVID-19 disrupted trends in the epidemiological transition, reversing long-standing progress.

    COVID-19 was the second leading age-standardized cause of death in 2021, profoundly impacting global life expectancy. It decreased life expectancy approximately as much as reductions in communicable diseases and NCDs have improved over decades. The study suggests that improved life expectancy outcomes could be achieved by leveraging past successes in mortality reduction.

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  • Feeling lonely? It may affect how your brain reacts to food, new research suggests

    Feeling lonely? It may affect how your brain reacts to food, new research suggests

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    In a recent study published in JAMA Network Open, researchers investigated the associations between individuals’ perceived levels of social isolation and brain patterns related to food cues, psychological outcomes, and obesity.

    Their results indicate that loneliness can lead to challenges in control and motivation when responding to foods and have important implications for the development of effective treatments for obesity.

    ​​​​​​​Study: Social Isolation, Brain Food Cue Processing, Eating Behaviors, and Mental Health Symptoms. Image Credit: Mansoreh/Shutterstock.com​​​​​​​Study: Social Isolation, Brain Food Cue Processing, Eating Behaviors, and Mental Health Symptoms. Image Credit: Mansoreh/Shutterstock.com

    Background

    Perceived social isolation, or loneliness, is known to have significant impacts on health, including mental health disorders, cardiovascular disease, and obesity. The negative health consequences of social isolation were widely documented during the coronavirus disease 2019 (COVID-19) pandemic.

    The biological mechanisms that underlie loneliness include alterations in brain networks like the default mode network, executive control network, visual attention network, and reward network, which could lead to hypervigilance to perceived social threats, heightened self-rumination, and increased sensitivity to negative social cues.

    They may also contribute to maladaptive behaviors like overeating and substance cravings.

    Investigating the neural mechanisms that link loneliness to alterations in responses to food cues may yield important insights into what scientists have termed the ‘lonely brain’ phenomenon.

    About the study

    In this study, researchers hypothesized that loneliness is associated with increased activation in certain brain regions when viewing food cues, which correlates with worsened mental health, changed eating behaviors, and obesity measures.

    Another key hypothesis was that sweet food-related neural alterations would show stronger associations with maladaptive eating behaviors and mental health outcomes due to the well-documented rewarding nature of sugar-rich foods.

    Healthy, premenopausal female participants were recruited in Los Angeles and asked to report perceived social isolation using the Perceived Isolation Scale.

    They went through functional magnetic resonance imaging (fMRI) while being exposed to various food cues to evaluate neural responses to different food types.

    Various clinical and behavioral measures were examined, including body composition, eating behaviors, and mental health variables.

    Statistical analyses were conducted to compare demographic and clinical characteristics between high and low-perceived isolation groups. Whole-brain analyses were performed to assess perceived isolation-related differences in neural responses to the cues.

    Regions of interest (ROIs) were identified, and brain signal changes were extracted for further analysis. Multiple linear regression analyses examined associations between loneliness-related brain food cue reactivity and individual clinical and behavioral measures.

    Mediation analyses were conducted to assess the mediating effect of brain food cue reactivity on the association between perceived isolation and various outcomes of interest, such as body measurements, eating behaviors, and mental health. All analyses were adjusted for age.

    Findings

    Overall, 93 female participants aged 18 to 50 years, with a mean age of 25.38 years, were included, with 41% self-identifying as Filipino and 59% as Mexican.

    The high perceived isolation group (n=39) exhibited poorer diet quality, greater fat mass percentage, poorer mental health, and increased maladaptive eating behaviors compared to the low perceived isolation group (n=54).

    The findings from whole-brain comparisons showed that the group perceiving higher levels of social isolation reacted significantly more strongly to cues when viewing foods compared to non-foods, particularly in the region of the inferior parietal lobule (IPL).

    Specifically, when they viewed sweet foods compared to non-foods, increased reactivity was observed in multiple brain regions, including the lateral occipital cortex, inferior frontal gyrus, and IPL.

    Conversely, when they were shown savory foods compared to non-foods, the group perceiving higher levels of isolation exhibited less reactivity to cues in the dorsolateral prefrontal cortex (dlPFC) and central praecuneus.

    Brain reactivity to sweet groups only and all food groups was correlated with mental health indicators and maladaptive food consumption behaviors. However, no associations were found for the subsample of savory foods.

    When participants were shown food compared to non-food, brain reactivity was observed to mediate the correlations with reward-based eating, food cravings, and generally maladaptive eating behaviors.

    Similarly, when participants viewed sweet food compared to non-food, brain reactivity was seen to mediate associations with body fat percentage, reward-based eating, food cravings, and generally maladaptive eating behaviors.

    The association between viewing savory food and positive affect was also mediated by brain reactivity.

    Conclusions

    This study reveals that loneliness is linked to obesity, mental health symptoms, and maladaptive eating behaviors.

    Being lonely was associated with increased body fat; lonely individuals were also more likely to report maladaptive eating behaviors and increased vulnerability to psychological symptoms.

    Brain imaging showed heightened reactivity to cues in brain regions associated with social cognition and executive control, suggesting an imbalance in sensitivity to internal states and external cues.

    Sweet foods particularly influenced neural responses, potentially due to their rewarding nature and analgesic effect.

    These findings underscore the role of altered brain processing in mediating the association between social isolation and adverse health outcomes, highlighting the importance of holistic interventions targeting both body and mind.

    Journal reference:

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  • Study highlights COVID-19 challenges for perinatal women in Latino communities

    Study highlights COVID-19 challenges for perinatal women in Latino communities

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    Public policies blocked many families of Mexican descent living in the U.S. from accessing vital services such as food and mental health care during the COVID-19 pandemic, even though these communities experienced some of the highest infection and mortality rates.

    Thirty-eight perinatal women and mothers of young children were interviewed about the challenges they faced during the pandemic and proposed solutions to better meet the needs of their communities during future large-scale crises in a study led by University of Illinois Urbana-Champaign kinesiology and community health professor Sandraluz Lara-Cinisomo.

    Co-authors of the study are molecular anthropologist Amy L. Non of the University of California-San Diego; Kimberly D-Anna-Hernandez, a professor of psychology at Marquette University; and U. of I. graduate student Mary Ellen Mendy and undergraduate students Jessica Avalos and Jacqueline Marquez.

    The women in the study discussed the stressors they encountered during the pandemic, including their difficulties accessing mental health treatment, child care and food. Their suggestions and insights were used to identify actionable policies and programs that could help meet the needs of Latino communities during future emergencies.

    The participants, who were interviewed between September 2021 and December 2022, were part of a longitudinal study that recruited them from a clinic in San Diego, one of the U.S. cities with large Latino populations of Mexican heritage.

    The women were about 36 years old on average. Although about 81% of them were born in Mexico, many had resided in the U.S. for 17 years or more. About 31% reported having an annual household income of less than $21,000, while a similar percentage earned $40,000 or more, according to the study.

    Lara-Cinisomo said participants faced complex stressors during the pandemic. Half of the women in the study said their families had challenges obtaining food due to loss of income and subsidies such as school lunches, as well as supply chain shortages and consumer stockpiling.

    While early in the pandemic various federal and state programs and policies were deployed to mitigate people’s risks for exposure and enhance families’ economic security, millions of tax-paying families of Mexican descent and other Latino backgrounds were excluded because of restrictions and exclusions set by those programs.”

    Sandraluz Lara-Cinisomo, University of Illinois Urbana-Champaign kinesiology and community health professor

    The researchers found that more than twice as many Spanish speakers reported food-related issues compared with their English-speaking counterparts.

    “Policymakers should consider how language barriers increase the risks of Spanish-speaking families losing out on benefits designed to meet their needs, such as CalFresh,” California’s iteration of the federal SNAP food assistance program for low-income people, Lara-Cinisomo said.

    “Communicating food and health and safety information in linguistically appropriate media, such as texts, videos or commercials, is vital to ensure accessibility to people with differing literacy and technological skills and should be carefully considered by policymakers.”

    Involving trusted sources in disseminating relevant and critical information was also recommended by the participants. For marginalized communities that have experienced historical discrimination and anti-immigrant propaganda, trust in these sources is vital, Lara-Cinisomo said.

    “Research has shown that community engagement is critical in emergency preparedness and increases the likelihood of meeting the needs of marginalized communities,” Lara-Cinisomo said. Accordingly, she and her team recommended developing a contingency plan to train culturally and linguistically competent community health workers to cultivate networks of trusted community members to assist in crisis communication efforts.

    Some women discussed feeling anxiety about the uncertainties associated with the pandemic, such as lockdowns and conflicting health information. These feelings were exacerbated by employment disruptions, pregnancy, and food access problems, and their concerns extended to family members residing in other households and those living in Mexico, participants told the researchers.

    The majority of those interviewed advocated broadening access to food subsidy programs such as WIC and SNAP to offset income losses and food shortages during large-scale crises, along with providing public awareness campaigns about local food banks and assistance programs.

    Even though California provides more services for undocumented immigrants -; including paid family leave and one year of emergency coverage with mental health services under Medi-Cal, the state’s Medicaid plan, for pregnant women -; caring for their mental health needs was a significant problem for many participants. Fifteen women reported needing mental health care, but twice as many of the English-speaking women mentioned these issues compared with their Spanish-speaking counterparts, the researchers found.

    The researchers hypothesized that this difference may have been associated with cultural beliefs, with Spanish-speaking women feeling less comfortable disclosing mental health problems because of stigmatization compared with those who spoke English. Or, it may have been that those who spoke Spanish were more resilient or more concerned about immediate needs such as food assistance, the team said.

    Participants recommended broadening access to mental health services for mothers and their families, promoting awareness with providers and patients, and disseminating mental health information and resources through videos and other media and via programs such as WIC.

    Many of the women -; largely those who spoke only Spanish -; reported difficulties obtaining personal protective equipment and sanitization supplies because of shortages, consumer stockpiling, and price gouging, in keeping with other studies that showed low-income and marginalized communities were disproportionately affected.

    Although the study sample was small, Lara-Cinisomo said it highlighted critical needs for responsive, culturally appropriate policies and programs to ensure the well-being of Mexican-descent perinatal women and mothers of young children during public health crises.

    Lara-Cinisomo discussed the team’s findings and study participants’ recommendations during a virtual Briefing on Perinatal Health and Well-being on April 3 hosted by the journal Health Affairs, which published the study.

    Source:

    Journal reference:

    Lara-Cinisomo, S., et al. (2024). Solutions From Mexican-Descent Perinatal Women To Pandemic-Related Food, Mental Health, And Health And Safety Stressors. Health Affairs. doi.org/10.1377/hlthaff.2023.01492.

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  • Novel SARS-CoV-2 mutations found in floodwaters near homeless communities

    Novel SARS-CoV-2 mutations found in floodwaters near homeless communities

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    In a recent study published in the journal Environmental Science & Technology Letters, researchers conducted environmental surveillance to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in two flood control channels in the United States (US), influenced by homeless individuals. They detected SARS-CoV-2 RNA (short for ribonucleic acid) and novel spike gene mutations in the channels during COVID-19 (short for coronavirus disease 2019) outbreaks, emphasizing the efficacy of environmental surveillance for assessing public health in the homeless population.

    Study: Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene. Image Credit: CROCOTHERY / Shutterstock

    Study: Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene. Image Credit: CROCOTHERY / Shutterstock

    Background

    During the COVID-19 pandemic, overwhelmed public health laboratories in the US prompted the initiation of the National Wastewater Surveillance System (NWSS) to support traditional surveillance efforts in March 2020. The program could effectively detect SARS-CoV-2 RNA, antimicrobial resistance markers, and emerging variants, offering early detection for public health priorities. Several studies have reported the presence of viruses and human fecal material in flood control channels due to various factors like overflowing sanitary sewers and direct human inputs. In cities where homelessness is common, environmental surveillance of flood control channels can aid in understanding disease transmission among people experiencing homelessness, which is often overlooked in clinical surveillance data.

    RNA of SARS-CoV-2 can sustain in water bodies for extended periods, while infected individuals can continue shedding significant amounts of viral RNA in fecal matter for up to seven months. Despite previous research demonstrating the presence of SARS-CoV-2 RNA in surface waters, conducting whole genome sequencing (WGS) from flood control channels for variant identification is less frequent, primarily due to difficulties in collecting and analyzing samples. Researchers in the present study aimed to identify SARS-CoV-2 RNA in environmental water samples from flood control infrastructure impacted by homeless individuals, perform WGS, compare variants with those found in the local community, and potentially reveal any novel mutations.

    About the study

    In the present study, water sample processing was performed by concentrating primary effluent from wastewater treatment plants (WWTPs) using hollow fiber ultrafiltration, followed by extraction and synthesis of cDNA (short for complementary deoxyribonucleic acid). Environmental water samples from two sources (Flamingo Wash and Tropicana Wash) were processed similarly. A total of 57 samples were collected and analyzed.

    SARS-CoV-2 RNA quantification was performed using quantitative polymerase chain reaction (qPCR). Further, library preparation for amplicon-based WGS made use of a SARS-CoV-2 panel and Illumina NextSeq 500. Data analysis included adapter trimming, read alignment, primer masking, variant calling, and determination of variant composition. Low-frequency and novel mutations were identified and validated using various databases.

    Results and discussion

    SARS-CoV-2 RNA was detected in 15 samples (33% in treated water and 20% in freshwater), with concentrations between 2.8 and 4.8 log10 gc/L. Higher detection frequencies occurred in the first two months of 2022, corresponding to the peak of the first Omicron wave. This aligns with the maximal concentrations observed at the WWTP. PMMoV (short for pepper mild mottle virus), a fecal indicator virus, was detected in almost all samples, with concentrations between 4.0 and 6.3 log10 gc/L, consistent with previous studies. Detection frequencies of PMMoV were slightly higher in this study than in earlier ones, possibly due to the increased sensitivity of sample processing methods or the study of areas with higher densities of unsheltered individuals.

    The detected variants were majorly classified as Omicron, Delta, and Alpha, especially in environmental water samples. Notably, Alpha detection in freshwater indicated potential persistent shedding or low circulation levels. Delta variant signals were observed, correlating with shedding timelines, suggesting variable loadings could influence variant composition in environmental samples.

    Previously unreported mutations of the SARS-CoV-2 spike protein, including Tyr636Phe, Ser943Thr, and Phe1103Val, were identified in the samples. These mutations, not residing in the receptor-binding domain (RBD), were observed more than once, with Tyr636Phe being the most frequently detected. While the origin and significance of these mutations remain uncertain, their presence suggests potential circulation within the local community rather than being unique to flood control channels or municipal wastewater.

    The findings suggest that COVID-19 transmission within unsheltered populations may reflect trends in the general community. However, a direct comparison of variant prevalence could not be made due to limited clinical surveillance data for unsheltered individuals.

    Conclusion

    In conclusion, the study found that the SARS-CoV-2 variants detected in environmental water samples influenced by human waste from homeless individuals were like those circulating in the broader community, as observed through wastewater and clinical surveillance. The highest concentrations of SARS-CoV-2 RNA coincided with the peak of the initial Omicron surge, followed by a decline correlating with decreased wastewater concentrations and confirmed case counts. The study emphasizes the utility of environmental surveillance for understanding public health conditions and infectious disease transmission, particularly among vulnerable homeless populations.

    Journal reference:

    • Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene. Anthony Harrington et al., Environmental Science & Technology Letters (2024), DOI: 10.1021/acs.estlett.3c00938, https://pubs.acs.org/doi/10.1021/acs.estlett.3c00938 

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  • End of internet subsidies for low-income households threatens telehealth access

    End of internet subsidies for low-income households threatens telehealth access

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    It’s also how much she spent on her monthly internet bill before the federal Affordable Connectivity Program stepped in and covered her payments.

    “When you have low income and you are living on disability and your daughter’s disabled, every dollar counts,” said Westman, who lives in rural Illinois.

    More than 23 million low-income households — urban, suburban, rural, and tribal — are enrolled in the federal discount program Congress created in 2021 to bridge the nation’s digital connectivity gap. The program has provided $30 monthly subsidies for internet bills or $75 discounts in tribal and high-cost areas.

    But the program is expected to run out of money in April or May, according to the Federal Communications Commission. In January, FCC Chairwoman Jessica Rosenworcel asked Congress to allocate $6 billion to keep the program running until the end of 2024. She said the subsidy gives Americans the “internet service they need to fully participate in modern life.”

    The importance of high-speed internet was seared into the American psyche by scenes of children sitting in parking lots and outside fast-food restaurants to attend school online during the covid-19 pandemic. During that same period, health care providers and patients like Westman say, being connected also became a vital part of today’s health care delivery system.

    Westman said her internet connection has become so important to her access to health care she would sell “anything that I own” to stay connected.

    Westman, 43, lives in the small town of Eureka, Illinois, and has been diagnosed with genetic and immune system disorders. Her 12-year-old daughter has cerebral palsy and autism.

    She steered the $30 saved on her internet toward taking care of her daughter, paying for things such as driving 30 minutes west to Peoria, Illinois, for two physical therapy appointments each week. And with an internet connection, Westman can access online medical records, and whenever possible she uses telehealth appointments to avoid the hour-plus drive to specialty care.

    “It’s essential for me to keep the internet going no matter what,” Westman said.

    Expanding telehealth is a common reason health care providers around the U.S. — in states such as Massachusetts and Arkansas — joined efforts to sign their patients up for the federal discount program.

    “This is an issue that has real impacts on health outcomes,” said Alister Martin, an emergency medicine physician at Massachusetts General Hospital. Martin realized at the height of the pandemic that patients with means were using telehealth to access covid care. But those seeking in-person care during his ER shifts tended to be lower-income, and often people of color.

    “They have no other choice,” Martin said. “But they probably don’t need to be in the ER action.” Martin became a White House fellow and later created a nonprofit that he said has helped 1,154 patients at health centers in Boston and Houston enroll in the discount program.

    At the University of Arkansas for Medical Sciences, a federal grant was used to conduct dozens of outreach events and help patients enroll, said Joseph Sanford, an anesthesiologist and the director of the system’s Institute for Digital Health & Innovation.

    “We believe that telehealth is the great democratization to access to care,” Sanford said. New enrollment in the discount program halted nationwide last month.

    Leading up to the enrollment halt, Sen. Peter Welch (D-Vt.) led a bipartisan effort to introduce the Affordable Connectivity Program Extension Act in January. The group requested $7 billion — more than the FCC’s ask — to keep the program funded. “Affordability is everything,” Welch said.

    In December, federal regulators surveyed program recipients and found that 22% reported no internet service before, and 72% said they used their ACP-subsidized internet to “schedule or attend healthcare appointments.”

    Estimates of how many low-income U.S. households qualify for the program vary, but experts agree that only about half of the roughly 50 million eligible households have signed on.

    “A big barrier for this program generally was people don’t know about it,” said Brian Whitacre, a professor and the Neustadt chair in the Department of Agricultural Economics at Oklahoma State University.

    Whitacre and others said rural households should be signing up at even higher rates than urban ones because a higher percentage of them are eligible.

    Yet, people found signing up for the program laborious. Enrollment was a two-step process. Applicants were required to get approved by the federal government then work with an internet service provider that would apply the discount. The government application was online — hard to get to if you didn’t yet have internet service — though applicants could try to find a way to download a version, print it, and submit the application by mail.

    When Frances Goli, the broadband project manager for the Shoshone-Bannock Tribes in Idaho, began enrolling tribal and community members at the Fort Hall Reservation last year, she found that many residents did not know about the program — even though it had been approved more than a year earlier.

    Goli and Amber Hastings, an AmeriCorps member with the University of Idaho Extension Digital Economy Program, spent hours helping residents through the arduous process of finding the proper tribal documentation required to receive the larger $75 discount for those living on tribal lands.

    “That was one of the biggest hurdles,” Goli said. “They’re getting denied and saying, come back with a better document. And that is just frustrating for our community members.”

    Of the more than 200 households Goli and Hastings aided, about 40% had not had internet before.

    In the tribal lands of Oklahoma, said Sachin Gupta, director of government business and economic development at internet service provider Centranet, years ago the funding may not have mattered.

    “But then covid hit,” Gupta said. “The stories I have heard.”

    Elders, he said, reportedly “died of entirely preventable causes” such as high blood pressure and diabetes because they feared covid in the clinics.

    “It’s really important to establish connectivity,” Gupta said. The end of the discounts will “take a toll.”




    Kaiser Health NewsThis article was reprinted from khn.org, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – the independent source for health policy research, polling, and journalism.

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  • Wastewater surveillance reveals COVID-19 transmission patterns in unsheltered encampments

    Wastewater surveillance reveals COVID-19 transmission patterns in unsheltered encampments

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    To better understand COVID-19’s spread during the pandemic, public health officials expanded wastewater surveillance. These efforts track SARS-CoV-2 levels and health risks among most people, but they miss people who live without shelter, a population particularly vulnerable to severe infection. To fill this information gap, researchers reporting in ACS’ Environmental Science & Technology Letters tested flood-control waterways near unsheltered encampments, finding similar transmission patterns as in the broader community and identifying previously unseen viral mutations.

    In recent years, testing untreated wastewater for SARS-CoV-2 incidence and dominant viral variants, as well as other pathogens, has been vital to helping public health officials determine infectious disease transmission in local communities. Yet, this monitoring only captures information on viruses shed from human feces and urine in buildings that are connected to local sewage infrastructure. Beyond the pandemic’s impact on human health, it also exacerbated socioeconomic difficulties and increased the number of people experiencing homelessness and living in open-air encampments without access to indoor bathrooms. To understand the prevalence of COVID-19 among people who live unsheltered, Edwin Oh and colleagues tested for SARS-CoV-2 in waterways near encampments outside Las Vegas from December 2021 through July 2022.

    Using quantitative polymerase chain reaction, the researchers identified SARS-CoV-2 RNA in more than 25% of the samples tested from two flood-control channels. The highest detection frequency over the study period aligned with Las Vegas’ first wave of omicron variant infections, as confirmed through parallel testing at a local wastewater treatment plant. The researchers say these results suggest a similar level of transmission was occurring within the unsheltered community as it was among the general population. Then the researchers conducted whole genome sequencing to identify the SARS-CoV-2 variants in the waterways. These samples largely contained the same variants identified in the broader community. Deeper computational analysis of the viral sequences identified three novel viral spike protein mutations in some waterway samples, but the researchers have not yet examined what impact these mutations might have on viral function or clinical outcomes. Regardless, the ability to detect and identify SARS-CoV-2 in environmental water samples could help improve public health measures for a community that is often underrepresented in current surveillance methods. The researchers also say monitoring waterways could warn health officials of unexpected variants circulating in the community.

    Source:

    Journal reference:

    Harrington, A., et al. (2024) Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene. Environmental Science & Technology Letters. doi.org/10.1021/acs.estlett.3c00938.

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  • New study reveals increased risk of allergic diseases after COVID-19 infection

    New study reveals increased risk of allergic diseases after COVID-19 infection

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    A recent study published in Nature Communications explored the association of COVID-19 with long-term allergic conditions.

    Study: Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK. Image Credit: wavebreakmedia/Shutterstock.comStudy: Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK. Image Credit: wavebreakmedia/Shutterstock.com

    Background

    The severe respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, and led to the declaration of a coronavirus disease 2019 (COVID-19) pandemic in March 2020. It caused over seven million deaths and many times that number of infections and hospitalizations.

    Additionally, nearly half of COVID-19 cases have to deal with delayed or chronic morbidity, which may have set in during or after the acute phase of infection. These are called post-COVID-19 conditions or post-acute sequelae of COVID-19 (PASC), otherwise known as long COVID.

    Symptoms of PASC, in some cases, include immunologic phenomena that may cause allergic conditions of various kinds.

    About the study

    The study aimed to investigate how ethnicity affects allergic conditions following COVID-19. Researchers formed a synthetic group comprising over 22 million individuals from South Korea, Japan, and the UK, drawing participants from multinational studies to represent these ethnic backgrounds. S

    pecifically, the South Korean segment included more than 800,000 people with an average age of 48. From the UK and Japan, the cohorts included over 325,000 and 2.5 million participants, respectively.

    Within these groups, approximately 150,000 participants from South Korea, 77,000 from the UK, and 542,000 from Japan had been infected with SARS-CoV-2. This large-scale analysis aimed to shed light on the ethnic variations in post-COVID-19 allergic reactions.

    What were the findings?

    After adjusting for all known variables that could affect the outcome, the researchers discovered that individuals infected with SARS-CoV-2 showed a 20% higher occurrence of allergic diseases compared to those not infected.

    This increased risk was consistent for infections from both the original and Delta variants of the virus. Specifically, the likelihood of developing asthma in those infected was more than double, at 2.25 times that in non-infected individuals.

    The chance of getting allergic rhinitis was 25% higher in the infected group, though no significant increase was observed for food allergies or atopic dermatitis.

    Moreover, while the risk for allergic diseases decreased over time after the infection, it didn’t disappear entirely. This decrease in risk varied from country to country.

    Severity of infection and allergy risk

    Moderate-to-severe COVID-19 was linked to a 50% higher risk of overall allergy, compared to 14% among those with mild disease.

    COVID-19 vaccination and allergy risk

    Those who had received the vaccine had a 44% higher risk of allergy (with one dose). This was reduced by 20% after two doses of the vaccine. The two-dose cohort had comparable allergy risk as the controls, both overall and for the various allergy subgroups.

    Other factors like coexisting morbidity, drinking, body mass index, exercise, and the SARS-CoV-2 strain responsible for the infection, did not show significant correlation with allergy risk.

    Conclusions

    This is the first study that provides comprehensive evidence for the association between SARS-CoV-2 infection and subsequent incident allergic outcomes.”

    It emphasizes the relationship between COVID-19, especially moderate to severe, and subsequent allergy onset. It also indicates that COVID-19 vaccination with at least two doses weakens the risk of new allergies.

    The findings broadly corroborate earlier research, but there is a need for more studies on the allergic sequelae of COVID-19 on a larger and more multinational scale.

    Multiple pathways have been proposed to account for the observed correlations, including T cell disruption, regulatory T cell (Treg) disturbances, and the cytokine storm in acute severe COVID-19.     

    Over time, the virus may be slowly cleared from the host, especially if adaptive immunity has been strengthened by vaccination against the virus.

    The study underlines “a need for persistent health policies to manage the severity of SARS-CoV-2 infection.” People with a history of COVID-19 should be aware that they are at higher risk for allergic manifestations in the short-term future, at least.

    Journal reference:

    • Oh, J., Lee, M., Kim, M., et al. Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK. Nature Communications. doi: https://doi.org/10.1038/s41467-024-47176-w.

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  • More patients are losing their doctors — and trust in the primary care system

    More patients are losing their doctors — and trust in the primary care system

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    First, her favorite doctor in Providence, Rhode Island, retired. Then her other doctor at a health center a few miles away left the practice. Now, Piedad Fred has developed a new chronic condition: distrust in the American medical system.

    “I don’t know,” she said, her eyes filling with tears. “To go to a doctor that doesn’t know who you are? That doesn’t know what allergies you have, the medicines that make you feel bad? It’s difficult.”

    At 71, Fred has never been vaccinated against covid-19. She no longer gets an annual flu shot. And she hasn’t considered whether to be vaccinated against respiratory syncytial virus, or RSV, even though her age and an asthma condition put her at higher risk of severe infection.

    “It’s not that I don’t believe in vaccines,” Fred, a Colombian immigrant, said in Spanish at her home last fall. “It’s just that I don’t have faith in doctors.”

    The loss of a trusted doctor is never easy, and it’s an experience that is increasingly common.

    The stress of the pandemic drove a lot of health care workers to retire or quit. Now, a nationwide shortage of doctors and others who provide primary care is making it hard to find replacements. And as patients are shuffled from one provider to the next, it’s eroding their trust in the health system.

    The American Medical Association’s president, Jesse Ehrenfeld, recently called the physician shortage a “public health crisis.”

    “It’s an urgent crisis, hitting every corner of this country, urban and rural, with the most direct impact hitting families with high needs and limited means,” Ehrenfeld told reporters in October.

    In Fred’s home state of Rhode Island, the percentage of people without a regular source of routine health care increased from 2021 to 2022, though the state’s residents still do better than most Americans.

    Hispanic residents and those with less than a high school education are less likely to have a source of routine health care, according to the nonprofit organization Rhode Island Foundation.

    The community health centers known as federally qualified health centers, or FQHCs, are the safety net of last resort, serving the uninsured, the underinsured, and other vulnerable people. There are more than 1,400 community health centers nationwide, and about two-thirds of them lost between 5% and a quarter of their workforce during a six-month period in 2022, according to a report by the National Association of Community Health Centers.

    Another 15% of FQHCs reported losing between a quarter and half of their staff. And it’s not just doctors: The most severe shortage, the survey found, was among nurses.

    In a domino effect, the shortage of clinicians has placed additional burdens on support staff members such as medical assistants and other unlicensed workers.

    Their extra tasks include “sterilizing equipment, keeping more logs, keeping more paperwork, working with larger patient loads,” said Jesse Martin, executive vice president of District 1199 NE of the Service Employees International Union, which represents 29,000 health care workers in Connecticut and Rhode Island.

    “When you add that work to the same eight hours’ worth of a day’s work you can’t get everything done,” Martin said.

    Last October, scores of SEIU members who work at Providence Community Health Centers, Rhode Island’s largest FQHC, held an informational picket outside the clinics, demanding improvements in staffing, work schedules, and wages.

    The marketing and communications director for PCHC, Brett Davey, declined to comment.

    Staff discontent has rippled through community health care centers across the country. In Chicago, workers at three health clinics held a two-day strike in November, demanding higher pay, better benefits, and a smaller workload.

    Then just before Thanksgiving at Unity Health Care, the largest federally qualified health center in Washington, D.C., doctors and other medical providers voted to unionize. They said they were being pressed to prioritize patient volume over quality of care, leading to job burnout and more staff turnover.

    The staffing shortages come as community health centers are caring for more patients. The number of people served by the centers between 2015 and 2022 increased by 24% nationally, and by 32.6% in Rhode Island, according to the Rhode Island Health Center Association, or RIHCA.

    “As private practices close or get smaller, we are seeing patient demand go up at the health centers,” said Elena Nicolella, RIHCA’s president and CEO. “Now with the workforce challenges, it’s very difficult to meet that patient demand.”

    In Rhode Island, community health centers in 2022 served about 1 in 5 residents, which is more than twice the national average of 1 in 11 people, according to RIHCA.

    Job vacancy rates at Rhode Island’s community health centers are 21% for physicians, 18% for physician assistants and nurse practitioners, and 10% for registered nurses, according to six of the state’s eight health centers that responded to a survey conducted by RIHCA for The Public’s Radio, NPR, and KFF Health News.

    Pediatricians are also in short supply. Last year, 15 pediatricians left staff positions at the Rhode Island health centers, and seven of them have yet to be replaced.

    Research shows that some of the biggest drivers of burnout are workload and job demands.

    Community health centers tend to attract clinicians who are mission-driven, said Nelly Burdette, who spent years working in health centers before becoming a senior leader of the nonprofit Care Transformation Collaborative of Rhode Island.

    These clinicians often want to give back to the community, she said, and are motivated to practice “a kind of medicine that is maybe less corporate,” and through which they can they develop close relationships with patients and within multigenerational families.

    So when workplace pressures make it harder for these clinicians to meet their patients’ needs, they are more likely to burn out, Burdette said.

    When a doctor quits or retires, Carla Martin, a pediatrician and an internist, often gets asked to help. The week before Thanksgiving, she was filling in at two urgent care clinics in Providence.

    “We’re seeing a lot of people coming in for things that are really primary care issues, not urgent care issues, just because it’s really hard to get appointments,” Martin said.

    One patient recently visited urgent care asking for a refill of her asthma medication. “She said, ‘I ran out of my asthma medicine, I can’t get a hold of my PCP for refill, I keep calling, I can’t get through,’” Martin said.

    Stories like that worry Christopher Koller, president of the Milbank Memorial Fund, a nonprofit philanthropy focused on health policy. “When people say, ‘I can’t get an appointment with my doctor,’ that means they don’t have a usual source of care anymore,” Koller said.

    Koller points to research showing that having a consistent relationship with a doctor or other primary care clinician is associated with improvements in overall health and fewer emergency room visits.

    When that relationship is broken, patients can lose trust in their health care providers.

    That’s how it felt to Piedad Fred, the Colombian immigrant who stopped getting vaccinated. Fred used to go to a community health center in Rhode Island, but then accessing care there began to frustrate her.

    She described making repeated phone calls for a same-day appointment, only to be told that none were available and that she should try again tomorrow. After one visit, she said, one of her prescriptions never made it to the pharmacy.

    And there was another time when she waited 40 minutes in the exam room to consult with a physician assistant — who then said she couldn’t give her a cortisone shot for her knee, as her doctor used to do.

    Fred said that she won’t be going back.

    So what will she do the next time she gets sick or injured and needs medical care?

    “Well, I’ll be going to a hospital,” she said in Spanish.

    But experts warn that more people crowding into hospital emergency rooms will only further strain the health system, and the people who work there.

    This article is from a partnership that includes The Public’s Radio, NPR, and KFF Health News.




    Kaiser Health NewsThis article was reprinted from khn.org, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – the independent source for health policy research, polling, and journalism.

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  • Ministers of Health commit to accelerated action against malaria in Africa

    Ministers of Health commit to accelerated action against malaria in Africa

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    Ministers of Health from African countries with the highest burden of malaria committed today to accelerated action to end deaths from the disease. They pledged to sustainably and equitably address the threat of malaria in the African region, which accounts for 95% of malaria deaths globally.

    The Ministers, gathering in Yaoundé, Cameroon, signed a declaration committing to provide stronger leadership and increased domestic funding for malaria control programmes; to ensure further investment in data technology; to apply the latest technical guidance in malaria control and elimination; and to enhance malaria control efforts at the national and sub-national levels.

    The Ministers further pledged to increase health sector investments to bolster infrastructure, personnel and programme implementation; to enhance multi-sectoral collaboration; and to build partnerships for funding, research and innovation. In signing the declaration, they expressed their “unwavering commitment to the accelerated reduction of malaria mortality” and “to hold each other and our countries accountable for the commitments outlined in this declaration.”

    The Yaoundé conference, co-hosted by the World Health Organization (WHO) and the Government of Cameroon, gathered Ministers of Health, global malaria partners, funding agencies, scientists, civil society organizations and other principal malaria stakeholders.

    The ministerial conference has four key aims: review progress and challenges in achieving the targets of the WHO global malaria strategy; discuss mitigation strategies and funding for malaria; agree on effective strategies and responses for accelerated malaria mortality reduction in Africa; and establish a roadmap for increased political commitment and societal engagement in malaria control, with a clear accountability mechanism.

    “This declaration reflects our shared commitment as nations and partners to protect our people from the devastating consequences of malaria. We will work together to ensure that this commitment is translated into action and impact,” said Hon Manaouda Malachie, Minister for Health of Cameroon.

    The African region is home to 11 countries that carry approximately 70% of the global burden of malaria: Burkina Faso, Cameroon, Democratic Republic of the Congo, Ghana, Mali, Mozambique, Niger, Nigeria, Sudan, Uganda and Tanzania. Progress against malaria has stalled in these high-burden African countries since 2017 due to factors including humanitarian crises, low access to and insufficient quality of health services, climate change, gender-related barriers, biological threats such as insecticide and drug resistance and global economic crises. Fragile health systems and critical gaps in data and surveillance have compounded the challenge.

    Funding for malaria control globally is also inadequate. In 2022, US$ 4.1 billion – just over half of the needed budget – was available for malaria response.

    Globally the number of cases in 2022 was significantly higher than before the COVID-19 pandemic, rising to 249 million from 233 million in 2019. In the same period, the African region saw an increase in cases from 218 million to 233 million. The region continues to shoulder the heaviest malaria burden, representing 94% of global malaria cases and 95% of global deaths, an estimated 580 000 deaths in 2022.

    Globally, the world has made significant progress against malaria in recent decades and yet, since 2017, that progress has stalled. The COVID-19 pandemic and long-standing threats like drug and insecticide resistance pushed us further off-track, with critical gaps in funding and access to tools to prevent, diagnose and treat malaria. With political leadership, country ownership and the commitment of a broad coalition of partners, we can change this story for families and communities across Africa.”


    Dr. Tedros Adhanom Ghebreyesus, WHO Director-General

    To help accelerate efforts to reduce the malaria burden, WHO and the RBM Partnership to End Malaria launched the “High burden to high impact” approach in 2018, a targeted effort to accelerate progress in countries hardest hit by malaria.

    The declaration signed at today’s conference is aligned with the “High burden to high impact” approach, which is founded on four pillars: political will to reduce malaria deaths; strategic information to drive impact; better guidance, policies and strategies; and a coordinated national malaria response.

    “Malaria continues to cause preventable deaths in children and great devastation to families across our region. We welcome today’s ministerial declaration, which demonstrates a strong political will to reduce the burden of this deadly disease,” said Dr Matshidiso Moeti, WHO Regional Director for Africa. “With renewed urgency and commitment, we can accelerate progress towards a future free of malaria.”

    To put malaria progress back on track, WHO recommends robust commitment to malaria responses at all levels, particularly in high-burden countries; greater domestic and international funding; science and data-driven malaria responses; urgent action on the health impacts of climate change; harnessing research and innovation; as well as strong partnerships for coordinated responses. WHO is also calling attention to the need to address delays in malaria program implementation.

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