Browsing Tag
Small Molecules
11 posts
Targeted protein relocalization via protein transport coupling
Kau, T. R., Way, J. C. & Silver, P. A. Nuclear transport and cancer: from mechanism to intervention.…
Catalytic asymmetric synthesis of meta benzene isosteres
Salomen, L. M., Ellermann, M. & Diederich, F. Aromatic rings in chemical and biological recognition: energetics and structures.…
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
Kaupp, U. B. & Seifert, R. Molecular diversity of pacemaker ion channels. Annu. Rev. Physiol. 63, 235–257 (2001).…
Sapio Sciences launches new multimodal registration capabilities for its lab informatics platform
Sapio Sciences, the science-awareTM lab informatics platform, today announced the launch of its new multimodal registration capabilities. This new…
AI techniques massively accelerate the search for Parkinson’s disease treatments
Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson’s disease treatments. The researchers, from…
Metrion Biosciences enhances High Throughput Screening services with access to Enamine compound libraries
Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organization (CRO) and drug…
Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli
Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic…
Researchers forge new path to combat viruses and cancers with helicase inhibitors
Helicases are enzymes that unwind DNA and RNA. They’re central to cellular life, implicated in a number of…
Targeted protein degradation via intramolecular bivalent glues
Chemical synthesis Additional details are provided in the Supplementary Methods. Plasmids and oligonucleotides The design and construction of the…
Study suggests high levels of vitamin B3 breakdown products are linked to higher risk of mortality, heart attacks, and stroke
In a recent study published in Nature Medicine, researchers utilized an untargeted metabolomics technique to look for new…