Browsing Tag
Synthetic biology
25 posts
Meet the Plant Hacker Creating Flowers Never Seen (or Smelled) Before
The money he earned doing that was enough to put Cocioba through the first couple of years of…
Synthetic GPCRs for programmable sensing and control of cell behaviour
Plasmid constructs and cloning Constructs used for transient expression in HEK293T cells were cloned into the pAAV viral…
Single-molecule states link transcription factor binding to gene expression
Spitz, F. & Furlong, E. E. M. Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet.…
Five structural-biology questions that still challenge AI
Alena Khmelinskaia wants designing bespoke proteins to be as simple as ordering a meal. Picture a vending machine,…
Engineered odorant receptors illuminate the basis of odour discrimination
Buck, L. & Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor…
Engineered receptors show how humans tell countless odour molecules apart
Nature, Published online: 30 October 2024; doi:10.1038/d41586-024-03396-0 How do odorant receptors in the human nose recognize a wide…
AI-designed DNA sequences regulate cell-type-specific gene expression
Nature, Published online: 23 October 2024; doi:10.1038/d41586-024-03170-2 Researchers have used artificial-intelligence models to create regulatory DNA sequences that…
Machine-guided design of cell-type-targeting cis-regulatory elements
Training Malinois, a model of MPRA activity of CREs To enable systematic evaluation of parameters governing data preprocessing,…
Transferrin receptor targeting chimeras for membrane protein degradation
Mayle, K. M., Le, A. M. & Kamei, D. T. The intracellular trafficking pathway of transferrin. Biochim. Biophys.…
Designed endocytosis-inducing proteins degrade targets and amplify signals
Computational design of sortilin minibinders as Sort_EndoTags Using a Rosetta-based binder design protocol15, 21,000 binders were generated to…