Browsing Tag
Targeted therapies
4 posts
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Chemistry Compound 1 (ZINC21803075, D475-1631) was purchased from ChemDiv, and the synthesis of compounds 2–6 is described in…
April 24, 2024
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Cell culture and reagents Most cell lines were obtained from ATCC (listed in Supplementary Methods). Pa14C and Pa16C cells…
April 8, 2024
TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers
June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. N. Engl. J. Med. 379, 64–73 (2018). Article …
March 27, 2024
Transcription–replication conflicts underlie sensitivity to PARP inhibitors
Cell culture and drug treatments The human cervical cell line HeLa and the human osteosarcoma cell line U2OS…
March 20, 2024