Browsing Tag
Transcriptomics
27 posts
Why tumour geography matters — and how to map it
To people with cancer, tumours can seem like amorphous clumps of defective cells, relentlessly focused on unconstrained growth…
Cellular atlases are unlocking the mysteries of the human body
ITAI YANAI: Exploring human systems with cellular maps When early European naturalists travelled to South America, they revelled…
Single-cell integration reveals metaplasia in inflammatory gut diseases
Patient samples and tissue processing Healthy tissue from adults Healthy adult gastrointestinal tissue was obtained by the Cambridge…
An integrated transcriptomic cell atlas of human neural organoids
Metadata curation and harmonization of human neural organoid scRNA-seq datasets We included 33 human neural organoid data from…
Spatially restricted immune and microbiota-driven adaptation of the gut
Parikh, K. et al. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 567, 49–55 (2019).…
understanding RNA’s strangest form yet
RNA can adopt many configurations in the cell (artist’s illustration).Credit: Christoph Burgsted/Science Photo Library/Getty Over the past few…
Identification and genetic dissection of convergent persister cell states
Bacterial strains and culture conditions E. coli MG1655, UPEC CFT073, and derivative mutant strains (Supplementary Table 6) were…
Targeting immune–fibroblast cell communication in heart failure
Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428–435 (2008). Article ADS CAS PubMed Google Scholar …
Childhood leukaemia in Down’s syndrome primed by blood-cell bias
Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-02785-9 An in-depth investigation of gene regulation and cell populations at sites…
The heart is put at risk of rupture by cells bordering damaged tissue
Nature, Published online: 28 August 2024; doi:10.1038/d41586-024-02436-z After a heart attack, cardiac muscle cells at the border between…