Browsing Tag
Tumour immunology
12 posts
Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
Patients and treatment The trial was termed GDFATHER, for GDF-15 antibody-mediated human effector cell relocation (ClinicalTrials.gov NCT04725474). This…
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers
Mlecnik, B. et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival…
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
Cell lines YUMM1.7 and YUMM3.3 mouse melanoma62 cell lines (obtained from M. Bosenberg, Yale University) were cultured in Dulbecco’s…
Immune responses in checkpoint myocarditis across heart, blood and tumour
Haslam, A. & Prasad, V. Estimation of the percentage of US patients with cancer who are eligible for…
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer
Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.…
Transgelin 2 guards T cell lipid metabolism and antitumour function
Lim, S. A., Su, W., Chapman, N. M. & Chi, H. Lipid metabolism in T cell signaling and…
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Animals Six- to eight-week-old female CD45.2+Thy1.2+ C57BL/6 (C57BL/6J) mice, CD45.1+ mice (B6.SJL-Ptprca Pepcb/BoyCrl) and NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice…
Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
Islami, F., Goding Sauer, A., Gapstur, S. M. & Jemal, A. Proportion of cancer cases attributable to excess…
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Tumour samples Tumour samples were collected from individuals with melanoma, non–small cell lung cancer, ovarian cancer, and breast…
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Mice All mice used in this study were on a C57BL/6J genetic background and purchased from the Jackson…