Browsing Tag
X-ray crystallography
5 posts
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
Phillips, N. The coronavirus is here to stay — here’s what that means. Nature 590, 382–384 (2021). Article …
Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis
Felnagle, E. A. et al. Nonribosomal peptide synthetases involved in the production of medically relevant natural products. Mol.…
Single phage proteins sequester signals from TIR and cGAS-like enzymes
Manik, M. K. et al. Cyclic ADP ribose isomers: production, chemical structures, and immune signaling. Science 377, eadc8969…
Computational design of soluble and functional membrane protein analogues
AF2seq design protocol Design target preparation The design target structures were sourced from the Protein Data Bank (PDB)…
Discovery of potent small-molecule inhibitors of lipoprotein(a) formation
Compounds Chemical synthesis and characterization of the compounds were performed as indicated in the Supplementary Information. Recombinant protein expression…