Hybrid protein filaments are a surprise twist in neurodegeneration

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Nature, Published online: 02 October 2024; doi:10.1038/d41586-024-03054-5

Abnormal filaments of a single type of protein are hallmarks of neurodegeneration. Structural studies reveal filaments made from two discrete but interwoven proteins, giving clues about the origin of neurodegenerative conditions.

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