Browsing Tag
Chromatin
13 posts
Single-molecule states link transcription factor binding to gene expression
Spitz, F. & Furlong, E. E. M. Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet.…
Rapid homologue juxtaposition during meiotic chromosome pairing
Zickler, D. & Kleckner, N. Meiosis: dances between homologs. Annu. Rev. Genet. 57, 1–63 (2023). Article CAS PubMed …
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Animals and tissues Tet2−/− mice were generated as described41. These mice used in this study were backcrossed for…
Researchers elucidate how gene mutation mechanism causes autism
Researchers show how mutations of gene transcription and chromatin regulation-related genes cause autism. The loss-of-function mutation of KMT2C, a…
Neuroscientists identify age-defying RNAs in the brain
Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists…
Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children
Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United…
Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows
Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire…
Synthetic reversed sequences reveal default genomic states
Design of synthetic loci The synthetic HPRT1 locus has been described previously18. The synthetic HPRT1R locus was designed…
Study sheds light on the composition of nuclear matrix in Arabidopsis thaliana
Chromatin is a unique DNA and protein complex that makes up the chromosomes. Specific proteins (histones) wind up…
WNT signalling control by KDM5C during development affects cognition
Reprogramming of patient-derived fibroblasts Patient-derived fibroblasts were cultured in DMEM (Life Technologies, 11995073) supplemented with 10% FBS (Invitrogen,…