Browsing Tag
Drug development
9 posts
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
Xie, X. P. et al. Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following…
Fate induction in CD8 CAR T cells through asymmetric cell division
Lentiviral constructs and production, in vitro transcription, cell lines and cell culture All cells in this study were…
Google DeepMind’s Groundbreaking AI for Protein Structure Can Now Model DNA
Google spent much of the past year hustling to build its Gemini chatbot to counter ChatGPT, pitching it…
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Chemistry Compound 1 (ZINC21803075, D475-1631) was purchased from ChemDiv, and the synthesis of compounds 2–6 is described in…
Refining the impact of genetic evidence on clinical success
Definition of metrics Except where otherwise noted, we define genetic support of a drug mechanism (that is, a…
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Cell culture and reagents Most cell lines were obtained from ATCC (listed in Supplementary Methods). Pa14C and Pa16C cells…
TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers
June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. N. Engl. J. Med. 379, 64–73 (2018). Article …
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Taylor, C. T. & McElwain, J. C. Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible…
Drug targeting in psychiatric disorders — how to overcome the loss in translation?
Howes, O. D. & Baxter, L. The drug treatment deadlock in psychiatry and the route forward. World Psychiatry…