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  • More kids are dying of drug overdoses. Could pediatricians do more to help?

    More kids are dying of drug overdoses. Could pediatricians do more to help?

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    A 17-year-old boy with shaggy blond hair stepped onto the scale at Tri-River Family Health Center in Uxbridge, Massachusetts.

    After he was weighed, he headed for an exam room decorated with decals of planets and cartoon characters. A nurse checked his blood pressure. A pediatrician asked about school, home life, and his friendships.

    This seemed like a routine teen checkup, the kind that happens in thousands of pediatric practices across the U.S. every day — until the doctor popped his next question.

    “Any cravings for opioids at all?” asked pediatrician Safdar Medina. The patient shook his head.

    “None, not at all?” Medina said again, to confirm.

    “None,” said the boy named Sam, in a quiet but confident voice.

    Only Sam’s first name is being used for this article because if his full name were publicized he could face discrimination in housing and job searches based on his prior drug use.

    Medina was treating Sam for an addiction to opioids. He prescribed a medication called buprenorphine, which curbs cravings for the more dangerous and addictive opioid pills. Sam’s urine tests showed no signs of the Percocet or OxyContin pills he had been buying on Snapchat, the pills that fueled Sam’s addiction.

    “What makes me really proud of you, Sam, is how committed you are to getting better,” said Medina, whose practice is part of UMass Memorial Health.

    The American Academy of Pediatrics recommends offering buprenorphine to teens addicted to opioids. But only 6% of pediatricians report ever doing do, according to survey results.

    In fact, buprenorphine prescriptions for adolescents were declining as overdose deaths for 10- to 19-year-olds more than doubled. These overdoses, combined with accidental opioid poisonings among young children, have become the third-leading cause of death for U.S. children.

    “We’re really far from where we need to be and we’re far on a couple of different fronts,” said Scott Hadland, the chief of adolescent medicine at Mass General for Children and a co-author of the study that surveyed pediatricians about addiction treatment.

    That survey showed that many pediatricians don’t think they have the right training or personnel for this type of care — although Medina and other pediatricians who do manage patients with addiction say they haven’t had to hire any additional staff.

    Some pediatricians responded to the survey by saying they don’t have enough patients to justify learning about this type of care, or don’t think it’s a pediatrician’s job.

    “A lot of that has to do with training,” said Deepa Camenga, associate director for pediatric programs for the Yale Program in Addiction Medicine. “It’s seen as something that’s a very specialized area of medicine and, therefore, people are not exposed to it during routine medical training.”

    Camenga and Hadland said medical schools and pediatric residency programs are working to add information to their curricula about substance use disorders, including how to discuss drug and alcohol use with children and teens.

    But the curricula aren’t changing fast enough to help the number of young people struggling with an addiction, not to mention those who die after taking just one pill.

    In a twisted, deadly development, drug use among adolescents has declined — but drug-associated deaths are up.

    The main culprits are fake Xanax, Adderall, or Percocet pills laced with the powerful opioid fentanyl. Nearly 25% of recent overdose deaths among 10- to 19-year-olds were traced to counterfeit pills.

    “Fentanyl and counterfeit pills is really complicating our efforts to stop these overdoses,” said Andrew Terranella, the Centers for Disease Control and Prevention’s expert on adolescent addiction medicine and overdose prevention. “Many times these kids are overdosing without any awareness of what they’re taking.”

    Terranella said pediatricians can help by stepping up screening for — and having conversations about — all types of drug use.

    He also suggests pediatricians prescribe more naloxone, the nasal spray that can reverse an overdose. It’s available over the counter, but Terranella, who practices in Tucson, Arizona, believes a prescription may carry more weight with patients.

    Back in the exam room, Sam was about to get his first shot of Sublocade, an injection form of buprenorphine that lasts 30 days. Sam is switching to the shots because he didn’t like the taste of Suboxone, oral strips of buprenorphine that he was supposed to dissolve under his tongue. He was spitting them out before he got a full dose.

    Many doctors also prefer to prescribe the shots because patients don’t have to remember to take them every day. But the injection is painful. Sam was surprised when he learned that it would be injected into his belly over the course of 20-30 seconds.

    “Is it almost done?” Sam asked, while a nurse coaches him to breathe deeply. When it was over, staffers joked out loud that even adults usually swear when they get the shot. Sam said he didn’t know that was allowed. He’s mostly worried about any residual soreness that might interfere with his evening plans.

    “Do you think I can snowboard tonight?” Sam asked the doctor.

    “I totally think you can snowboard tonight,” Medina answered reassuringly.

    Sam was going with a new buddy. Making new friends and cutting ties with his former social circle of teens who use drugs has been one of the hardest things, Sam said, since he entered rehab 15 months ago.

    “Surrounding yourself with the right people is definitely a big thing you want to focus on,” Sam said. “That would be my biggest piece of advice.”

    For Sam, finding addiction treatment in a medical office jammed with puzzles, toys, and picture books has not been as odd as he thought it would be.

    He mom, Julie, had accompanied him to this appointment. She said she’s grateful the family found a doctor who understands teens and substance use.

    Before he started visiting the Tri-River Family Health Center, Sam had seven months of residential and outpatient treatment — without ever being offered buprenorphine to help control cravings and prevent relapse. Only 1 in 4 residential programs for youth offer it. When Sam’s cravings for opioids returned, a counselor suggested Julie call Medina.

    “Oh my gosh, I would have been having Sam here, like, two or three years ago,” Julie said. “Would it have changed the path? I don’t know, but it would have been a more appropriate level of care for him.”

    Some parents and pediatricians worry about starting a teenager on buprenorphine, which can produce side effects including long-term dependence. Pediatricians who prescribe the medication weigh the possible side effects against the threat of a fentanyl overdose.

    “In this era, where young people are dying at truly unprecedented rates of opioid overdose, it’s really critical that we save lives,” said Hadland. “And we know that buprenorphine is a medication that saves lives.”

    Addiction care can take a lot of time for a pediatrician. Sam and Medina text several times a week. Medina stresses that any exchange that Sam asks to be kept confidential is not shared.

    Medina said treating substance use disorder is one of the most rewarding things he does.

    “If we can take care of it,” he said, “We have produced an adult that will no longer have a lifetime of these challenges to worry about.”




    Kaiser Health NewsThis article was reprinted from khn.org, a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – the independent source for health policy research, polling, and journalism.

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  • Breast Cancer Now funds researchers to investigate targeted radiotherapy for metastatic breast cancer in the brain

    Breast Cancer Now funds researchers to investigate targeted radiotherapy for metastatic breast cancer in the brain

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    Researchers are trialing a new type of targeted radiotherapy to treat secondary breast cancer tumors in the brain, thanks to new funding from Breast Cancer Now.

    Image Credit: Breast Cancer Now

    Image Credit: Breast Cancer Now

    Secondary (or metastatic) breast cancer is when breast cancer spreads to other parts of the body. While it’s incurable, the disease can be treated, but treatments are limited when the cancer has spread to the brain.

    The most common treatment is whole-brain radiotherapy, which can cause serious side effects such as hair loss, nausea, vomiting, and fatigue, because healthy brain tissue receives the same dose of radiotherapy as the cancer.

    Breast Cancer Now has awarded £173,414 to Dr Matt Williams and his team at Imperial College London, who will investigate whether a type of targeted radiotherapy, called DE-iPTV VMAT, could be a more effective treatment for secondary breast cancer patients.

    This type of radiotherapy targets secondary breast cancer tumors in the brain while minimizing damage to healthy tissues, which should cause fewer side effects for patients than whole-brain radiotherapy.

    Everyone taking part in the clinical trial will receive this new type of radiotherapy so the researchers can assess its impact and how it affects patients’ quality of life.

    The team will also collect and analyze blood samples to see if it’s possible to tell who might benefit the most from this treatment.

    In addition, Dr Williams will be using national cancer data to develop a fuller picture of people whose breast cancer has spread to the brain, analyzing patients’ survival rates and use of health care services.

    Currently, there is no official record of the number of people living with secondary breast cancer or of their experience with the disease. Developing a broader understanding of these patients would help scientists develop kinder, cost-effective treatments and improve women’s quality of life.

    The team at Imperial hope that using this data and the results from the initial study will help them plan a larger clinical trial to test the benefits of targeted radiotherapy treatment more thoroughly.

    Dr Matt Williams, Consultant Clinical Oncologist at Imperial College Healthcare NHS Trust said: “We’ve developed a way to deliver radiotherapy that increases the dose that the tumors in the brain receive, while reducing the dose to the rest of the brain.

    “This targeted approach should be more effective in treating people with secondary breast cancer in the brain than whole-brain radiotherapy and have fewer side effects. But we need to see if it’s practical and works for patients.”

    Over 1,000 people with breast cancer receive radiotherapy for tumors in the brain each year in the UK. Most of them could benefit from a targeted radiotherapy that reduces the radiation to healthy brain tissue, which could improve the quality of life for people affected by the disease. With an estimated 61,000 people living with incurable secondary breast cancer in the UK, we hope our research could lead to more treatment options that give people more time to live their lives to the fullest.​”

    Dr Simon Vincent, Director of Research, Support and Influencing, Breast Cancer Now

    Scott Henniker from Birchington in Kent lost his wife, Hayley, to secondary breast cancer in 2020.  Hayley was diagnosed with HER2-positive breast cancer in 2014 and despite responding well to treatment, was given the devastating news that the breast cancer had spread to her brain in 2018.

    Scott says: “Hayley had an operation to remove the tumor in her brain and recovered well. She was always so positive, and you would not have known she was unwell. However, the cancer came back and for a time was kept under control by radiotherapy, but Hayley started to decline significantly from March 2020, and she sadly passed away in the August with our two kids and I beside her.”

    Scott is passionate about supporting research to find more targeted treatments to treat secondary breast cancer in the brain.

    Scott says: “Hayley received localized and whole brain radiotherapy and experienced all kinds of challenging side effects.  We watched her gradually become a completely different person to the one we knew and loved which was heartbreaking for our family. I support any research that is looking for more targeted and effective treatments for breast cancer that has spread to the brain, so that less people lose loved ones to this dreadful disease.”

    Breast Cancer Now is the research and support charity here for anyone affected by breast cancer. Call their free helpline on 0808 800 6000 to speak to their expert nurses or find out more and donate at breastcancernow.org

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  • Early puberty in first-born daughters linked to prenatal stress in their mothers

    Early puberty in first-born daughters linked to prenatal stress in their mothers

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    A UCLA-led team of researchers has found a correlation between early signs of adrenal puberty in first-born daughters and their mothers’ having experienced high levels of prenatal stress. They did not find the same result in boys or daughters who were not first-born.

    The 15-year longitudinal study’s findings were published in the February issue of Psychoneuroendocrinology.

    The study was the first to identify earlier patterns of adrenal puberty as a result of prenatal stress. Adrenal puberty is marked by changes like the growth of body hair, pimples and aspects of cognitive maturation, but does not include breast development or the onset of menstruation for girls or testicular enlargement for boys.

    The finding adds to research in the field of fetal programming, studies that explore the impact that stress and other factors affecting pregnant mothers can have on fetuses and children long after birth.

    “This is a first-of-its-kind finding and is fascinating to look at through an evolutionary lens,” said UCLA anthropologist Molly Fox, who led the study with colleagues from UC Irvine, UC Merced, Chapman University and the University of Denver.

    Fox explains that a first-born daughter’s maturation, but not early onset of menstruation, may enable her to help her mother rear her other children successfully. The daughter becomes mature enough to help take care of children while not yet able to produce her own children, who would require her attention.

    The finding also provides insights into the so-called “eldest daughter syndrome,” the socio-cultural phenomenon discussed online that refers to the childcare and other domestic labor that first-born females often take on, consciously or unconsciously, to help with the traditional parental or adult responsibilities required to run a household. The online discussions focus on oldest daughters feeling an overwhelming sense of responsibility for their family’s well-being.

    Researchers recruited participants for the study from two obstetric clinics in Southern California during routine first trimester prenatal care visits. The women were 30 years old on average, all 18 or older, and experiencing singleton pregnancies. For about half of them, this was their first pregnancy. All were English-speaking, 45% were white/non-Latina and 30% were Latina. All were nonsmoking and not using steroid medications, tobacco, alcohol or other recreational drugs during pregnancy. Of the children born to these mothers, 48% were female and 52% were male.

    Women’s stress, depression and anxiety levels were measured at 15-, 19-, 25-, 31- and 37-weeks’ gestation to create a prenatal psychological distress composite score. They were also assessed at two to three months postpartum to assign a postnatal distress composite score. The depression assessment asked respondents to rate the truth of statements such as “I felt lonely.” An example of an anxiety question was how often they felt particular symptoms, such as “jittery.”

    At ages 8–10, 11–12 and 13–16, children’s biomarkers of adrenal and gonadal puberty were separately measured, including body hair, skin changes, growth in height or growth spurts, breast development and the onset of menstruation (in females), voice changes and facial hair growth (in males). Hormone levels that are indicators of adrenal and gonadal puberty were measured through saliva samples at all assessment stages.

    The study also measured childhood adversity to account for other factors known to correlate to early maturation or signs of puberty in children and adolescents. These included the death of a parent or parental separation before age 5, the absence of the father and low income-to-needs ratios experienced at ages 7–9.

    This research adds to the body of knowledge in our field showing the significant and lifelong impacts to women and their offspring when it comes to prenatal emotional, environmental and other factors. This is important as we continue to come up with practical and policy solutions that contribute to greater access to healthcare and the general wellbeing of pregnant mothers.”

    Molly Fox, UCLA anthropologist 

    Source:

    Journal reference:

    Fox, M. M., et al. (2024). Mothers’ prenatal distress accelerates adrenal pubertal development in daughters. Psychoneuroendocrinology. doi.org/10.1016/j.psyneuen.2023.106671.

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  • Magnesium’s pivotal role in slowing aging’s impact

    Magnesium’s pivotal role in slowing aging’s impact

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    Aging is associated with many biological, physiological, and psychological changes, some of which include a decline in cognitive function, greying of hair, frailty, and increased risk of contracting certain diseases. Aging also increases the risk of chronic diseases such as diabetes, hypertension, and cardiovascular events.

    Most older adults experience chronic magnesium deficiency or hypomagnesemia, which may be due to low dietary magnesium content, reduced intestinal absorption, and increased urination. In a recent review published in the journal Nutrients, researchers discuss the role of magnesium in aging.

    Study: Magnesium and the Hallmarks of Aging. Image Credit: monticello / Shutterstock.comStudy: Magnesium and the Hallmarks of Aging. Image Credit: monticello / Shutterstock.com

    The role of magnesium in telomere attrition

    Telomeres are present at both ends of chromosomes, thereby protecting them from degradation and fusion with other chromosomes to preserve genetic information. Between 50-100 base pairs of telomeric DNA are lost after each cell division; therefore, telomeres shorten as age advances.

    When a telomere attains a critical short length, cells recognize it, and replication is attenuated, which results in cell senescence. Previous studies have indicated that magnesium maintains telomeric chromatin structure and integrity, as well as supports telomerase regulation.

    Genomic instability

    Genomic instability, which involves DNA damage, chromosomal abnormalities, and mutations, is a key driver of aging. Genomic instability occurs due to oxidative stress, epigenetic alterations, inadequate DNA repair, and telomere maintenance.

    Throughout the cell cycle, magnesium is essential for stabilizing chromatin assembly. Furthermore, DNA grooves have specific binding sites for magnesium, thereby demonstrating its role in DNA conformation.

    Insufficient magnesium levels cause DNA instability through oxidation stress, as various enzymes involved in DNA repair are activated by magnesium. Thus, magnesium plays a crucial role in the DNA replication process and preservation of genome stability.

    Epigenetic alterations

    Epigenetic alterations refer to the modification of genomic expression without alterations in DNA sequence. The epigenome can be altered through lifestyle factors, diets, and pharmaceutics. Additionally, the age-related inflammatory environment and inhibitory molecules released from stressed cells may lead to epigenetic alterations, which can modify cellular function.

    Several studies have highlighted the association of magnesium with epigenetics. For example, hypomagnesemia causes down-regulation of hepatic 11β-hydroxysteroid dehydrogenase-2 (Hsd11b2) promoters, which affect the metabolism of neonatal offspring.

    Loss of proteostasis

    Proteostasis alterations are associated with weak protein stability and misfolded proteins. Several age-related chronic diseases, such as Alzheimer’s and Parkinson’s disease, have been attributed to the dysregulation of proteostasis. Importantly, low magnesium levels in the brain may lead to many neurological disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease, and migraines. 

    Magnesium downregulates tumor-necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production, in addition to supporting the clearance of amyloid β (Aβ) precursor molecules by proteasomal degradation pathways. Magnesium also inhibits the N-methyl-D-aspartate (NMDA) receptor and increases excitatory neurotransmission.

    Mitochondrial dysfunction

    The mitochondria is involved in multiple cell signaling processes that determine cell fate, including cellular survival and death by apoptosis. Dysfunctional mitochondria can lead to the persistent reduction in cellular adenosine triphosphate (ATP) levels for prolonged periods, which may lead to chronic inflammation, cellular damage, and oxidative stress. These conditions are also linked with age-associated diseases, such as Alzheimer’s disease and Parkinson’s disease. 

    Magnesium binds with ATP to form the Mg-ATP complex. The presence of intracellular free magnesium has been associated with the development of hypertension and diabetes, both of which are conditions that are more prevalent in older adults. Low magnesium levels are also associated with oxidative stress damage through reduced lipid peroxidation and antioxidant enzyme activity.

    Cellular senescence

    Cellular senescence is associated with cellular stress and irreversible DNA damage. Additional features of aging include senescence-associated mitochondrial dysfunction, altered nutrient and stress signaling, and autophagy/mitophagy dysfunction.

    Certain cellular alterations that occur during senescence are similar to those caused by hypomagnesemia, including reduced protection against oxidative stress damage, cellular viability, cell cycle progression, and enhanced risk of transcription factor expression.

    Stem cell exhaustion

    Human tissues are maintained by stem cells due to their self-renewing capacity. More specifically, stem cells can differentiate into progenitor cells, from which various tissues are developed.

    Previous studies have shown that a reduction in the hemopoietic cells’ regenerative potential due to aging is associated with the reduced production of adaptive immune cells, which is otherwise known as immunosenescence.

    Magnesium is strongly linked with immune responses. For example, magnesium is a cofactor for the production of immunoglobulins (Ig), antibody-dependent cytolysis, macrophage response to lymphokines, and immune cell adherence.

    Conclusions

    Since the aging trajectory is variable, it can be modulated through magnesium intake and lifestyle changes. The current review discusses the importance of suitable magnesium levels throughout life, which may contribute to healthy aging.

    Journal reference:

    • Dominguez, L. J., Veronese, N., & Barbagallo, M. (2024). Magnesium and the Hallmarks of Aging. Nutrients 16(4); 496. doi:10.3390/nu16040496

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  • High maternal cortisol levels linked to unexpected birth problems

    High maternal cortisol levels linked to unexpected birth problems

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    A snippet of hair can reveal a pregnant person’s stress level and may one day help warn of unexpected birth problems, a study indicates.

    Washington State University researchers measured the stress hormone cortisol in hair samples of 53 women in their third trimester. Of that group, 13 women who had elevated cortisol levels later experienced unpredicted birth complications, such as an early birth or hemorrhaging.

    While more research is needed with larger groups, this preliminary finding could eventually lead to a non-invasive way to identify those at risk for such complications. The researchers reported their findings in the journal Psychoneuroendocrinology.

    There was otherwise nothing about these women that would suggest a disease or anything else complicating the pregnancy. This confirmed some hypotheses that levels of stress, related specifically to cortisol levels, might be associated with adverse birth outcomes.”


    Erica Crespi, a WSU developmental biologist and study’s corresponding author

    As part of the study, the participants all answered survey questions about their levels of psychological distress in addition to having cortisol measurements taken in the third trimester of pregnancy and after they gave birth. The women who experienced unexpected birth complications had elevated cortisol concentrations in their hair, a measure that indicates the stress hormone’s circulating levels in the body during the three months prior to collection. These women also reported feelings of stress, anxiety and depression, but on average, only high cortisol levels during pregnancy showed a strong link to adverse birth outcomes.

    Cortisol, a steroid hormone, rises in humans and many animals to help regulate the body’s response to stress, but prolonged high cortisol is associated with major health problems including high blood pressure and diabetes. Throughout pregnancy, cortisol levels naturally rise two to four times and peak during the third trimester, but the measurements in this study showed even more pronounced elevated cortisol levels among the women who had unexpected birth complications.

    “If this finding holds up, it could be a non-invasive way to get greater insight into who might be at risk because it is information we didn’t get from the survey,” said co-author Sara Waters, a WSU human development researcher. “This was not something we could find out just from asking people about their stress.”

    Two months after giving birth, the group that experienced birth complications continued to show elevated cortisol and gave survey answers indicating continued stress, anxiety and depression. At six months, their cortisol remained elevated, but they started to report lower psychological distress on the survey, which the authors noted might be a sign of recovery.

    Finding ways to reduce stress around birth could help improve outcomes for both infants and mothers, the researchers said. They point out that adverse birth outcomes are rising in the country. The U.S. also notoriously has one of the highest maternal mortality rates among developed countries, with deaths disproportionately impacting Black women and other people of color.

    More needs to be done to improve healthcare and support systems for pregnant people and new parents, Waters said. This study is also a reminder to expectant and new mothers to prioritize their health.

    “It’s very easy to sacrifice our own health and well-being to prioritize our children’s, especially when it feels like resources are scarce,” said Waters. “But our ability to show up as parents comes from a foundation of getting our needs met too – like the saying, ‘you can’t pour from an empty cup.’”

    This study involved an interdisciplinary research team at WSU. In addition to Crespi and Waters, co-authors include first author Jennifer Madigan, a Ph.D. candidate in stress physiology research; Maria Gartstein, a psychology professor; Jennifer Mattera, a psychology Ph.D. student; and Chris Connelly, an associate professor of kinesiology. This research received support from a WSU Grand Challenges Grant as well as interdisciplinary grants from the WSU College of Arts and Sciences, and the WSU Office of Research.

    Source:

    Journal reference:

    Madigan, J. A., et al. (2023). Perinatal hair cortisol concentrations linked to psychological distress and unpredicted birth complications. Psychoneuroendocrinology. doi.org/10.1016/j.psyneuen.2023.106921.

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