Browsing Tag
Neuroimmunology
13 posts
Engineered T cell therapy for central nervous system injury
GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators.Global, regional, and national burden of traumatic brain injury…
A γδ T cell–IL-3 axis controls allergic responses through sensory neurons
Perner, C. et al. Substance P release by sensory neurons triggers dendritic cell migration and initiates the type-2…
Fibrin drives thromboinflammation and neuropathology in COVID-19
Animals C57BL/6 mice and K18-hACE2 mice (strain: B6.Cg-Tg(K18-ACE2)2Prlmn/J) were purchased from the Jackson Laboratory. Fga−/− mice52 and Fggγ390–396A…
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
Ethical statement for animal experiments Animal experiments were approved by the Monash Animal Research Platform ethics committee and…
Children with multiple sclerosis have better outcomes if treated early and with high-efficacy therapies
A ground-breaking study – the largest of its kind globally – has found children with multiple sclerosis (MS)…
Venous-plexus-associated lymphoid hubs support meningeal humoral immunity
Kipnis, J. Multifaceted interactions between adaptive immunity and the central nervous system. Science 353, 766–771 (2016). Article CAS …
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Rothhammer, V. et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous…
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Single-nucleus RNA sequencing of human brain tissue Frozen superior frontal gyrus and fusiform gyrus tissue blocks and pathology…
Mitochondrial complex I activity in microglia sustains neuroinflammation
Mice and EAE The Cx3cr1-YFPcreERT2R26tdTomato fate mapping mouse was generated by crossing B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT2)Litt/WganJ52 with B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J)53, as previously described19,20.…
Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance…