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  • How CRISPR therapy could cure everything from cancer to infertility

    How CRISPR therapy could cure everything from cancer to infertility

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    THE bouts of terrible pain began further back than Victoria Gray can remember. Her grandmother would try to ease the discomfort with hot towels and medication, but it was fruitless. “I was born having to endure pain,” she says. “It was a life that I felt wasn’t worth living.”

    Gray has an inherited condition known as sickle cell disease, which causes red blood cells to form an abnormal “sickle” shape that can block capillaries, causing pain and sometimes organ damage. As Gray aged, her pain got worse. On one occasion, she temporarily lost the use of her arms and legs. By her 30s, Gray required in-home care. So, when she was offered the chance to become the first person to receive an experimental CRISPR gene-editing treatment, she took it.

    Today, four years after this took place, she no longer has episodes of pain and works full time. “Now my life is full of optimism,” she says.

    The treatment involved will probably be given the green light by regulators in the US, UK and Europe soon, which will make it the first CRISPR therapy to be approved. It won’t be the last.

    There is now no doubt that this technology – used to edit genes – can treat and potentially even cure a huge range of conditions. The only question is, just how far can it go? Will it be an expensive therapy used only occasionally? Or will it become so widely used that many of us will be getting a CRISPR jab to, say, lower our cholesterol levels and enable us to live longer, healthier lives?

    CRISPR gene editing exploded onto the…

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  • 1.6-billion-year-old steroid fossils hint at a lost world of microbial life

    1.6-billion-year-old steroid fossils hint at a lost world of microbial life

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    Molecular fossils found in ancient sedimentary rocks have unveiled a lost world of primitive eukaryotes that dominated aquatic ecosystems from at least 1.6 billion to 800 million years ago.

    The findings, published June 7 in Nature, come from laboratory analyses of rock samples from around the world that revealed remnants of primitive compounds called protosteroids. The majority of these molecules, which form in the process of creating steroids, were likely produced by primordial eukaryotes, relatively complex life-forms that today include animals, plants, algae and fungi, the researchers say. 

    Almost all eukaryotes produce molecules called steroids, like cholesterol, that are crucial components of cell membranes. Steroids don’t degrade easily and their remnants can be detected in sedimentary rocks as molecular fossils.

    The last common ancestor of all eukaryotes lived around 1.2 billion to more than 1.8 billion years ago. But scientists know almost nothing about the abundance, ecology and habitats of those early microorganisms. Molecular and physical fossils of eukaryotes dated to 800 million years ago have been found. But farther back in time, their physical fossils become scarce and molecular fossils of the steroids become undetectable. The existence of protosteroids had been predicted but it was unclear what they would look like — or if they could even be detected — until the researchers figured out a way to re-create those molecular footprints in the lab.

    “This study explains why we don’t see footprints of these guys in the rocks, as researchers were looking for the wrong thing,” says biologist Laura Katz, a biologist at Smith College in Northampton, Mass., who was not involved with the new work. “It fills a void in the fossil records.”

    A dearth of obvious eukaryote fossils before 800 million years ago led scientists to speculate that the ecosystem at that time was dominated by bacteria. Alternatively, primordial eukaryotes may have simply lacked strength in numbers to leave behind detectable steroid remnants. 

    Some scientists had a different explanation: What if some intermediate molecule in the chemical pathway that produces modern steroids was actually the end product of the process in primordial eukaryotes? This theory had been proposed by the biochemist Konrad Bloch, who won the Nobel Prize in physiology or medicine in 1964 for discovering the biosynthetic pathway of cholesterol.

    To test this, geochemist Jochen Brocks of the Australian National University in Canberra and colleagues artificially matured molecules made in the first few steps of steroid biosynthesis, including lanosterol and cycloartenol. That revealed what the compounds’ molecular fossils would look like. Then the researchers looked for these fossils in tarlike bitumens and oils extracted from ancient rocks from all over the world. 

    The researchers discovered a deluge of the protosteroids in samples ranging from deep to relatively shallow water environments. The oldest sample, dating back to 1.6 billion years ago, came from the Barney Creek Formation in Australia.

    “One of the greatest puzzles of early evolution is, why didn’t our highly capable eukaryotic ancestors come to dominate the world’s ancient waterways? Where were they hiding?” says Benjamin Nettersheim, a geobiologist at University of Bremen in Germany. “We show that the protosteroid-producing microorganisms were hiding in plain sight and were in fact abundant in the world’s ancient oceans and lakes all along.”

    While most bacteria produce a different molecule, called hopanoids, some bacteria also have the chemical tools to kick-start protosteroid production. But these bacteria exist in niche environments, such as methane seeps and hydrothermal vents. And their molecular footprints have not been found in sediments older than 800 million years, leading the researchers to conclude that eukaryotes dominated the ancient ecosystems.

    “Konrad Bloch would have been delighted, had he lived, to see this,” says MIT geobiologist Roger Summons, who wasn’t involved in the study. “This paper has elegantly confirmed his prediction that biosynthetic precursors to cholesterol reflect ancient life’s quest for improvement.” (Bloch died in 2000.)

    Making these steroid precursors requires less oxygen and energy, so that may have given the primordial eukaryotes an advantage in thriving in early Earth’s harsh low oxygen conditions, the researchers propose (SN: 10/30/15).

    “If true, [this study] suggests that we may be able to examine the stepwise evolution of eukaryotes at [an] unprecedented level of detail,” says evolutionary biologist Yosuke Hoshino of the GFZ German Research Centre for Geosciences in Potsdam, who was not involved in the study. “This is such a great opportunity to understand the evolution of complex life, which biologists have always dreamed of.”


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  • Lunar CapitalFX Review: Pros & Cons 2025

    Coupled with favorable trading conditions for clients, including low spreads, no trading fees, and a 50% deposit bonus, it’s a great opportunity for both partners and traders to succeed. Lunar CapitalFX is a solid choice for beginner traders due to its user-friendly platforms, competitive spreads, and educational resources. The low minimum deposit requirement makes it easy for new traders to get started, while the wide variety of account types and payment methods ensure flexibility.

    Contests, Giveaways, and, Bonus Offers

    • More in-depth issues can be addressed by sending the broker an email.
    • With Lunar CapitalFX, you always have control over your portfolio and the copied trades.
    • Lunar Capital does not charge deposit fees, and processing times range from instant to a few days.

    MetaTrader 4 is a great option if you use custom indicators or strategies as it provides the MQL4 library which you can use to create bespoke strategies. If you lack the programming skills, the MetaQuotes Marketplace provides a library of 10,000+ custom indicators from the MT4 community you can use. Offering incentives for reviews or asking for them selectively can bias the TrustScore, which goes against our guidelines.

    Risk Management

    Even better, if you expect a high-rank spread, then the black account can help you in this regard. This company has been providing opportunities for traders to invest in the market for a long time since 2011. A big advantage of this platform is that traders can easily determine the rate of low wages.

    You will get additional money to increase your margin if you activate the bonus. But first of all, you can not pay out the bonus, you can only use it to make more profit. For withdrawal of the bonus, you have to do a certain turnover in trading volume (The bonus amount in lots divided 2). In this review, we will show you all the details you need to know about Lunar CapitalFX.

    • With over 42 million accounts across 180 countries, Lunar Capital provides commission-free access to a wide variety of financial markets.
    • In addition, Lunar Capital provides extra services to its clients, including educational content, relevant information, bonuses, and customer support, which are readily available to resolve any issues.
    • Your virtual credit will be included in the demo account with 10,000$ in automatic funding.

    How is Lunar CapitalFX’s Customer service?

    More advanced traders might not be the biggest fans, but novice or occasional investors will find it easy to navigate. One of Pepperstone’s most notable features is its lightning-fast execution speeds. This is a feature that mid-level and advanced traders will appreciate. There are other broker platforms that charge zero pips and low or zero commissions. However, these pricing structures often come with other costs, such as high inactivity fees.

    The global entity is unregulated, and this means clients benefit from fewer account protections. However, Lunar Capital states that it provides clients with segregated accounts and negative balance protection. A welcome addition would be third-party account insurance (such as a policy from Lloyds of London), as seen at some other popular offshore brokers. Overall, I rate Lunar Capital as an innovative broker with a client-centric focus. Lunar Capital is a reliable and accessible online broker, catering to traders worldwide. With its extensive range of financial instruments, educational resources, and commission-free structure, it provides a solid platform for novice and experienced traders.

    This assessment delivers a transparent evaluation of Lunar Capital’s trading conditions, tools, support, regulatory standing, and overall suitability for traders. Dear Emranullah Azad,Thank you for sharing your experience, and we’re truly sorry to hear about the frustration caused. On average, this process takes about one hour, but depending on the network traffic and the commission fee chosen, it can take up to 48 hours. Transactions with higher fees are typically confirmed faster by the blockchain.If your funds haven’t been credited after 48 hours, please get in touch with us again. If there’s anything else we can help with, our live chat and team is always here for you.Kind regards,Lunar Capital Rep. This Lunar Capital review aims to give a clear view of the broker and its services.

    It is regulated by the FSC in Mauritius, the Mwali International Services Authority (MISA), and CySEC for European traders. The broker has also been operating for 12 years, which is a strong signal of safety in my book. The Lunar CapitalTrader has the least options for technical analysis too with 19 indicators, 11 drawing tools, and 7 timeframes.

    To be successful in online trading you need to go through many steps like practice, time, https://lunarcapital.net/ patience, and much more. Lunar CapitalFX gives you some of these opportunities so that you can deal with or defeat the market. The broker transmits clear-sighted market knowledge while maintaining the specific skills required to make money online, which will give you a much higher balance of profits from losses.

    What leverage is available for trading indices and commodities?

    One of Lunar Capital’s impressive features I found was the no swap fees on all of its accounts. This means you can hold CFD positions overnight without being charged interest or fees like non-Islamic accounts do, making the broker a solid pick if you trade stocks. I opened an MT5 Trading Account to test the broker’s trading conditions and I was impressed with the spreads Lunar Capital supplied.

    TopBrokers.com will not accept any liability for loss or damage as a result of reliance on the information on this site. Forex pairs, cryptocurrencies and CFDs are complex instruments and come with a high risk of losing money. You should carefully consider whether you understand how these instruments work and whether you can afford to take the high risk of losing your money.

    Lunar Capital offers excellent transparency with a fee structure that includes zero commissions and no deposit or withdrawal fees. With the added flexibility of high leverage and a wide range of tradable assets, it’s an appealing platform for traders who want to focus on their strategies without worrying about hidden costs. The Lunar CapitalTrader account is designed for beginners, offering 80 trading instruments, including 35 currency pairs, gold, silver, and other assets.

    The Lunar CapitalFX broker, for a long time in European countries, has been providing services to traders in more than 100 countries. You might be surprised, the company is currently serving more than 1,500,000 traders. Here, according to the ECN (electronic communication network) model, the platforms can be selected. With more than a decade of experience and 6.6 million trading accounts from over 100 countries, traders should be able to have trust in Lunar Capital. I like that Lunar Capital invested in developing a proprietary copy trading service, which it also launched as a mobile app. Traders may follow signal providers, which Lunar Capital refers to a Master Traders.

  • QuickBooks ProAdvisor Program for Accountants Intuit

    quickbooks proadvisor login download software

    BigRedConsulting has shared the download https://www.bookstime.com/articles/virtual-bookkeeping-assistant-for-your-business link of the installer file. You should be able to install your QB Desktop 2020 on your machine. Hopefully you didn’t encounter any issue to reactivate your license. If you have any questions or need further assistance with the migration process or anything else related to QuickBooks Desktop, please don’t hesitate to reach out. We’re here to help ensure a smooth transition and to support you in getting the most out of your QuickBooks experience.

    • Moreover, running and customizing reports helps ensure that your business remains compliant with financial regulations.
    • The program includes a subscription to QuickBooks Online Accountant software, training, certification opportunities, discounts, and marketing resources.
    • Scale confidently with multi-entity management designed to enhance productivity and profitability for the most complex operations.
    • You wouldn’t give a wrench to a lawyer or tracing paper to a plumber.
    • Launching Nov. 20, this exciting development has been shaped by invaluable feedback from a wide range of accounting firms and professionals.

    Download your version of QuickBooks Desktop

    quickbooks proadvisor login download software

    Intuit says they can not give me the code because they do not support 2020 any longer. Moreover, running and customizing reports helps ensure that your business remains compliant with financial regulations. Properly documented reports can also simplify the process during audits. It also allows you to tailor the information to meet specific needs. You can choose which data fields to include, apply filters to focus on particular aspects, and even brand your reports for consistency. QuickBooks Desktop 2022 and earlier versions, including QuickBooks Desktop Pro, Premier, Mac, and Enterprise Solutions v22, has been already discontinued.

    All about the reimagined ProAdvisor Program

    quickbooks proadvisor login download software

    By accessing and using this page you agree to the terms and conditions. Earn your QuickBooks Enterprise badge and add expertise to your firm and credibility to your marketing. Sign in to QuickBooks Online Accountant to access self-paced quickbooks proadvisor courses for your firm. You wouldn’t give a wrench to a lawyer or tracing paper to a plumber.

    Accounting solutions

    quickbooks proadvisor login download software

    And to better support multi-service firms, we’re introducing Intuit® Tax Advisor and Intuit ProConnect™ Tax training modules. In addition, we’re expanding our third-party app training, and overhauling the QuickBooks Online training and presentation accounting materials for your clients. Discount and list price subject to change at any time at Intuit’s sole discretion. If you add or remove services, your subscription fees will be adjusted accordingly. Such notice is not intended nor will it have the effect of relieving the Participant of any liability under this Agreement or applicable law. Our reimagined program marks the start of a new era of continued investment in the accounting industry, with more than 20 changes since the last refresh.

    • Moving forward, keeping your QuickBooks Desktop updated ensures you are utilizing a robust, secure, and efficient accounting tool that can adapt to the growing needs of your business.
    • Your ProAdvisor license number and other info are also in CAMPS.
    • Such notice is not intended nor will it have the effect of relieving the Participant of any liability under this Agreement or applicable law.
    • Elite-level ProAdvisors get access to contests, promotions, discounts, and exclusive industry events.

    Bypass busy work and streamline projects so you can do more than ever for your clients. Get QuickBooks Online, QuickBooks Payroll, and QuickBooks Time for free—plus, a range of discounts on other software, services, and supplies. As a ProAdvisor, you can download QuickBooks products you’ve purchased from your account portal. This portal is also known as the Customer Account Management Portal (CAMPs). So QuickBooks will not help a non-profit organization to download an older version. Well, if anyone has done the math, the online version cost 10x that of buying the disc and using that version for a couple of years.

    • The QuickBooks ProAdvisor program gives you access to exclusive discounts, tools, training, and events to help you retain talent and expand your business.
    • Now your clients won’t be interrupted by product updates.
    • I use the QuickBooks Online ProAdvisor program both for growing and running my own practice and for my college accounting classes where I use the training to grow the next generation of accountants and bookkeepers.
    • Accruing tax liabilities in accounting involves recognizing and recording taxes that a company owes but has not yet paid.
  • How ultrasound therapy could treat everything from ageing to cancer

    How ultrasound therapy could treat everything from ageing to cancer

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    IMAGINE a medical device that could treat an enormous range of our ills, both big and small. A gadget that showed promise for destroying cancerous tumours or obliterating the body fat associated with obesity. Or that was potentially effective against the likes of back pain and glaucoma – and that was even versatile enough to be considered as a tool for tackling depression or anxiety. Surprisingly, such technology exists. Even more surprisingly, it works simply by generating sound waves.

    While perhaps most familiar to us for its use in medical imaging, ultrasound has emerged in recent decades as an extraordinarily flexible medical tool. Using the heat that intense ultrasound waves generate, we can destroy tumours or other problematic tissue deep within the body without making any incisions. Dial down the intensity, meanwhile, and we can gain unprecedented access to the brain, shaking cells to change their behaviour in ways that seem to improve mental health. For good measure, ultrasound may even reverse signs of physical ageing and reduce the learning and memory problems associated with older age.

    “Ultrasound is already a ubiquitous tool in medicine,” says Nir Lipsman at Sunnybrook Research Institute in Toronto, Canada. “But there’s tremendous focus on it right now because of the different ways we could use it to treat different medical problems.”

    The potential applications are coming so thick and fast that they are outpacing our ability to understand why it is so effective. The question now is: can we figure out how ultrasound affects our cells, so the technology can reach its full potential?

    Medical imaging

    Ultrasound – high-frequency sound above 20 kilohertz –…

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  • One photon is all it takes to kick off photosynthesis

    One photon is all it takes to kick off photosynthesis

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    For photosynthesis, one photon is all it takes.

    Only a single particle of light is required to spark the first steps of the biological process that converts light into chemical energy, scientists report June 14 in Nature.

    While scientists have long assumed that the reactions of photosynthesis begin upon the absorption of just one photon, that hadn’t yet been demonstrated, says physical chemist Graham Fleming, of the University of California, Berkeley. He and colleagues decided “we would just look to see was it really true that one photon was enough to start the whole thing off.”

    The sunlight that falls on Earth’s surface seems brilliant to human eyes. But on small scales, that translates to a dribble of photons. Only a few tens of photons of the appropriate wavelengths of sunlight fall on a square nanometer per second, the scale of the tiny chlorophyll and bacteriochlorophyll molecules that are central to photosynthesis in plants and bacteria.

    Many laboratory experiments on photosynthesis use lasers, much more powerful light sources, to kick off the reactions. Instead, Graham and colleagues used a source of light that produces just two photons at a time. One photon served as a herald, going off to a detector to let researchers know when two photons were released. The other photon went into a solution containing photon-absorbing structures from the photosynthetic bacterium Rhodobacter sphaeroides. These structures, called light-harvesting 2 complexes, or LH2, are made up of two rings of bacteriochlorophyll and other molecules.

    In a normal photosynthesis reaction, LH2 absorbs a photon and passes its energy to another LH2 complex, and then another, like a game of hot potato. Eventually the energy reaches another type of ring, called the light-harvesting 1 complex, or LH1, which then passes it to the reaction center where the energy is finally converted into a form that the bacterium can use.

    In the experiment, there was no LH1, so the LH2 instead emitted a photon of a different wavelength than the first, a sign that energy had been transferred from the first ring of LH2 to the second, a first step of photosynthesis. The researchers detected that second photon, and by comparing the detection times to those of the initial herald photons, confirmed that the LH2 needed to absorb only one photon to kick things off.

    Plants and bacteria use different processes for photosynthesis, but the initial steps are similar enough that in plants, too, a single photon would set off the initial steps, Fleming says. However, in plants, multiple independently absorbed photons are needed in order to complete the reaction.

    The role of single photons isn’t surprising, says biochemist Richard Cogdell of the University of Glasgow in Scotland. The important thing the researchers have done, he says, is to demonstrate the new technique. “By doing this you’re able to essentially interrogate what will be happening in nature,” he says.  

    Some scientists suspect that photosynthesis relies on quantum physics (SN: 2/3/10). While it’s not clear whether the new technique could resolve the role of quantum effects, it could help scientists disentangle natural effects from artifacts of using intense sources of light in studies of photosynthesis.

    “You can really work out what’s happening in the early reactions in photosynthesis as it were outside,” says Cogdell, “[as if] you could shrink yourself down and watch these photons moving around.”


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  • Unearned Revenue 101: Key Insights for Your Business

    Sales revenue is the income generated by the sale of services and/or products. Working capital is the difference between a company’s current assets (what the company owns that adds value to it) and its current liabilities (what it owes). Here we will present the proper information related to unearned revenue that will cover its example, its type, and calculation.

    Unearned Revenue Journal Entries

    For example, a law firm may charge a $10,000 retainer for legal representation. The firm holds this amount as unearned revenue and deducts from it as they complete billable work. If the entire amount isn’t used, the firm may refund the client or apply the remaining balance to future services.

    We see that the cash account increases, but the unearned revenue liability account also increases. Per accrual accounting reporting standards, revenue must be recognized in the period in which it has been “earned”, rather than when the cash payment was received. Accounting for unearned revenue on your financial statements is crucial, both as an accurate record of your financial position and to ensure you retain the right information for the IRD. It’s important to note that specific reporting requirements may differ based on the industry and the unique circumstances of each transaction.

    Examples of Unearned Revenue

    If you have noticed, what we are actually doing here is making sure that the earned part is included in income and the unearned part into liability. The adjusting entry will always depend upon the method used when the initial entry was made. Online retailers may receive advance payments for pre-ordered products that have not been shipped yet.

    Likewise, the unearned revenue is a liability that the company records for the money that it receives in advance. Unearned revenue is most common among companies selling subscription-based products or other services that require prepayments. Classic examples include rent payments made in advance, prepaid insurance, legal retainers, airline tickets, prepayment for newspaper subscriptions, and annual prepayment for the use of software. The adjusting entry for unearned revenue will depend upon the original journal entry, whether it was recorded using the liability method or income method. Closing entries are typically made at the end of an accounting period, after financial statements have been prepared.

    Read testimonials and reviews from our customers who have achieved their goals with Baremetrics. Discover how businesses like yours are using Baremetrics to drive growth and success. Have an idea of how other SaaS companies are doing and see how your business stacks up. The best consultants, agencies, and specialized services to help you grow. Understanding why customers leave, using data and insights, is the first step to retaining them. Experiment and optimize your pricing to secure the largest customer base.

    • After James pays the store this amount, he has not yet received his monthly boxes, so Beeker’s Mystery Boxes would record $240 as unearned revenue in their records.
    • This helps finance teams maintain compliance and focus on higher-level financial strategy rather than fixing accounting errors.
    • According to the accounting reporting principles, unearned revenue must be recorded as a liability.
    • Accounts receivable represents money that you’re owed for work that has already been completed and has been invoiced and awaiting payment by your customer.

    When a customer pays for a monthly or annual subscription, the business receives the payment upfront but hasn’t yet provided the full service. For example, if a customer purchases a one-year Netflix plan for $120, Netflix can’t recognize the entire $120 as revenue immediately. Instead, it must classify it as unearned revenue and recognize $10 per month as earned revenue as the service is provided.

    Unearned revenue refers to money received for goods or services that have not been provided yet. While manual closing entries are foundational to understanding accounting principles, most modern businesses use software to streamline this process. These contents closing entries are automated in modern accounting software.

    However, since the business is yet to provide actual goods or services, it considers unearned revenue as liabilities, as explained further below. The entry for unearned revenue into the journal is always debited to the cash account and credited to the unearned revenue account. When a business receives an advance payment, it must classify the amount as unearned revenue under liabilities, not income or asset. The payment represents a company’s obligation to deliver a product or service in the future. Unearned revenue is money received by a business for goods or services that have not yet been delivered. It is classified as a liability on the balance sheet because the company still owes something to the customer.

    Unearned Revenue vs Deferred Revenue

    Earned revenue refers to revenue that a company has successfully delivered goods or services for and has been recognized on the income statement. Unearned revenue is money received for goods or services that have not yet been provided and is recorded as a liability. To record unearned revenue, you generally need to enter the amount in two places – as a credit to your unearned revenue account and a debit to your cash account.

    • Therefore, you will record unearned revenue on your balance sheet under short-term liabilities—unless you will deliver the products or services a year or more after receiving the prepayment.
    • By making closing entries at the end of an accounting period, accountants ensure that the financial statements reflect the true financial performance and position of the company for that period.
    • While understanding the manual process provides essential accounting knowledge, modern businesses benefit significantly from automating these procedures.
    • Under the liability method, you initially enter unearned revenue in your books as a cash account debit and an unearned revenue account credit.

    Unearned revenue in cash accounting and accrual accounting

    If the consideration received exceeds the fair value of the goods or services provided, the excess should be recognized as a liability or deferred income. If you expect to deliver the goods or services within a year, treat unearned revenue as a current liability. If it will take longer than a year, you may list it as a long-term, non-current liability. Unearned revenue, also referred to as deferred revenue or unearned income, is money your customer pays you for goods or services you haven’t yet delivered. Certain rules and guidelines for recognizing unearned revenue are applicable. Unearned revenue is documented on the liabilities side of the balance sheet.

    In the event of failing to meet any of the criteria, the company must stick to revenue recognition guidelines. Companies always adhere to the matching principle by deferring recognition of revenue. For help creating balance sheets that can track unearned revenue, consider using QuickBooks Online. QuickBooks offers a wide range of financial reporting capabilities, along with expense tracking and invoice features. Every business will have to deal with unearned revenue at some point or another. Small business owners must how to record unearned revenue determine how best to manage and report unearned revenue within their accounting journals.

    Suppose a SaaS company has collected upfront cash payment as part of a multi-year B2B customer contract. Baremetrics integrates directly with your payment processor, so information about your customers is automatically piped into the Baremetrics dashboards. Baremetrics is a business metrics tool that provides 26 metrics about your business, such as MRR, ARR, LTV, total customers, and more.

    When a customer prepays for a service, your business will need to adjust its unearned revenue balance sheet and journal entries. Your business will need to credit one account and debit another account with the correct amounts using the double-entry accounting method. A business will need to record unearned revenue in its accounting journals and balance sheet when a customer has paid in advance for a good or service which they have not yet delivered. Once it’s been provided to the customer, unearned revenue is recorded and then changed to normal revenue within a business’s accounting books. The deferred payments are recorded as current liabilities in the balance sheet of a company as the products or services are expected to be delivered within the current year.

    Baremetrics provides an easy-to-read dashboard that gives you all the key metrics for your business, including MRR, ARR, LTV, total customers, and more. Below is a break down of subject weightings in the FMVA® financial analyst program. As you can see there is a heavy focus on financial modeling, finance, Excel, business valuation, budgeting/forecasting, PowerPoint presentations, accounting and business strategy.

    In this article, I will go over the ins and outs of unearned revenue, when you should recognize revenue, and why it is a liability. Don’t worry if you don’t know much about accounting, as I’ll illustrate everything with some examples. On 31st May, a contractor received $100,000 for a project to be executed over ten months.

    Ramp simplifies this by offering bulk transaction categorization and AI-suggested accounting rules, ensuring each retainer is recorded and recognized accurately. At the end of the second quarter of 2020, Morningstar had $287 million in unearned revenue, up from $250 million from the prior-year end. The company classifies the revenue as a short-term liability, meaning it expects the amount to be paid over one year for services to be provided over the same period. Deferred revenue is a broader term that encompasses unearned revenue and other types of revenue that are received in advance but have not yet been recognised on the income statement.

  • 19th century painters may have primed their canvases with beer-brewing leftovers

    19th century painters may have primed their canvases with beer-brewing leftovers

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    McKenzie Prillaman was the Spring 2023 science writing intern at Science News. She holds a bachelor’s degree in neuroscience with a minor in bioethics from the University of Virginia and a master’s degree in science communication from the University of California, Santa Cruz.

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  • Microwaving an insecticide restores its mosquito-killing power

    Microwaving an insecticide restores its mosquito-killing power

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    Heating an insecticide can give it new life.

    Microwaving the insecticide deltamethrin rearranges its crystal structure but doesn’t change its chemical composition. The rearrangement renews deltamethrin’s ability to kill mosquitoes that have become resistant to the insecticide, researchers report April 21 in Malaria Journal.

    The researchers didn’t set out to revive insecticides, says Bart Kahr, a crystallographer at New York University. He and colleagues had been working on crystal growth experiments. “And it turns out that a very good crystal for the experiment that we wanted to do was DDT, the very old, notorious insecticide from the last century.” The researchers realized that DDT has two crystal forms, one of which works better than the other.

    They then started experimenting with deltamethrin, an insecticide that is commonly used against mosquitoes that can carry malaria. The chemical is often incorporated into bed nets or sprayed on walls or other surfaces in homes. Mosquitoes absorb the insecticide when they come in contact with it. Kahr and colleagues previously discovered that heating deltamethrin changed its crystal structure, which let it work faster (SN: 10/19/20).

    Altering the arrangement of crystals is a tried-and-true way of giving drugs new and different properties, Kahr says. But no one had thought to rearrange insecticide crystals to give them new life, he says. “We just were surprised at how relevant it really was, and a little surprised that nobody has looked at this before,” he says. “Different communities of scientists just have different urgencies. And sometimes when you come from the outside, you look at things from a completely different way.”

    Kahr’s team heated a chalk formulation of deltamethrin called D-Fense Dust either in an oven or in a microwave. In the oven, the researchers could precisely control the temperature, he says. “But just for kicks, we said because this deltamethrin is a consumer product, what if you just pop it in the microwave for five minutes? Does that achieve the same thing as heating it to a prescribed temperature in the oven?” The microwave worked just as well, but Kahr cautions that people shouldn’t use the same microwave for heating food and insecticides.

    Two microscope images of deltamethrin's crystal structure. The image on the left is the insecticide's typical crystal structure and the image on the right is of the crystal structure heated.
    Popping deltamethrin in the microwave for a few minutes rearranges the insecticide’s typical crystal structure (left). Tests of heated deltamethrin crystals (right) showed that they are effective against mosquitoes resistant to the insecticide’s usual form.Jingxiang Yang

    Previously, the researchers had tested the heated deltamethrin crystals on mosquitoes that were already sensitive to the insecticide. In the new study, the scientists teamed up with entomologists to test the heated crystals on five strains of Anopheles mosquitoes from West Africa that are resistant to deltamethrin. In all cases, the rearranged crystals killed the resistant mosquitoes.

    That’s important because insecticide resistance is a growing problem and is impairing the ability to control mosquito populations to tamp down malaria spread, says Janet Hemingway, a geneticist at the Liverpool School of Tropical Medicine in England who was not involved in the new study. “We’re now at the point where almost nowhere in Africa is fully susceptible.”

    It is encouraging that heated insecticide killed highly resistant mosquitoes, says Hemingway, who directs the Infection Innovation Consortium, a public-private effort to find new ways to combat infectious diseases. But, she says, “this is not something we can take and use that tomorrow.”

    For instance, insecticide-treated bed nets are made by mixing deltamethrin with fibers before yarn is extruded. The insecticide migrates to the outside of the yarn and forms crystals. Depending on the manufacturer, “the crystal structures that end up on the surfaces of those bed nets can be quite different,” Hemingway says.

    It’s not certain that the heat-treated deltamethrin would retain its more potent crystal structure through the net-making process. And you couldn’t just pop bed nets in the microwave to rearrange the deltamethrin crystals, she says. “You’d need some pretty big microwaves given these things come in shipping containers.”

    Kahr’s team is working on incorporating the heat-treated crystal into nets. Liquid sprays are out since the rearranged crystals don’t retain their structure when mixed into water. People could spray the heated chalk instead, but few people would probably want chalky walls, Kahr says. “There are all kinds of social and cultural things that you could propose from a scientific perspective that wouldn’t be welcomed by a community of homeowners.”


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  • Scientists may have found an antidote for death cap mushrooms

    Scientists may have found an antidote for death cap mushrooms

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    Death cap mushrooms get their name for a reason: The poisonous fungi can kill if ingested in even small amounts. But researchers may have found an antidote for one of the mushroom’s most deadly toxins.

    A dye already used in medical procedures can block damage from the mushroom’s alpha-amanitin toxin, researchers report May 16 in Nature Communications. The work was done with human cells grown in lab dishes and with mice. If the finding holds up in trials with people, the antidote has potential to save lives.

    Death cap mushrooms (Amanita phalloides) are responsible for the majority of deaths from mushroom poisonings worldwide. Symptoms may appear as soon as six hours after ingestion and include nausea, vomiting and diarrhea. If a person isn’t treated immediately, the toxins can cause liver and kidney damage that can lead to death within 48 hours after ingestion. There is no antidote currently available, but people can be treated with fluids, activated charcoal and other therapies.

    How alpha-amanitin kills isn’t fully understood. A team of researchers in China and Australia used the gene editor CRISPR/Cas9 to determine which human genes the toxin triggers to cause cell damage and death (SN: 10/7/20). One of those genes makes a protein called STT3B, which helps attach sugars to proteins. Scientists hadn’t known that that process was important for mushroom toxicity.

    The team then screened a library of more than 3,000 drugs approved by the U.S. Food and Drug Administration for molecules that could inhibit STT3B’s action. The team found that the dye indocyanine green could stop the protein from doing its job and prevent human cells in lab dishes from dying after being treated with alpha-amanitin.

    In tests with mice poisoned with alpha-amanitin, the dye reduced liver and kidney damage and increased survival rates if given one to four hours after poisoning. Waiting eight to 12 hours to administer the antidote reduced its effectiveness, the team found, probably because irreversible organ damage had already occurred.

    Tina Hesman Saey

    Tina Hesman Saey is the senior staff writer and reports on molecular biology. She has a Ph.D. in molecular genetics from Washington University in St. Louis and a master’s degree in science journalism from Boston University.


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